Confirmation of prostate cancer susceptibility genes using high-risk families.

G. P. Jarvik, J. L. Stanford, E. L. Goode, R. McIndoe, S. Kolb, M. Gibbs, L. Hood, E. A. Ostrander

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Data from many types of studies support the hypothesis that strong familial components are involved in the etiology of prostate cancer. One way to access such genes is through the study of families with multiple affected family members and, in particular, families with individuals affected comparatively early in life. Several prostate cancer susceptibility loci have been described to date. Confirmation of the linkage and estimation of the proportion of families who are linked in large independent datasets is essential to understanding the significance of susceptibility genes. We explore the methodology used to perform such studies and the factors that can limit the ability to confirm linkage results. We report specifically the example of the HPC1 gene on 1q24-25.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalJournal of the National Cancer Institute. Monographs
Issue number26
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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