Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8

De Fang Luo; Raffaella Buzzetti; Jerome I. Rotter; Noel K. Maclaren; Leslie J. Raffel; Lorenza Nisticò; Claudio Giovannini; Paolo Pozzilli; Glenys Thomson; Jin-Xiong She

doi:10.1093/hmg/5.5.693

Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8

De Fang Luo, Raffaella Buzzetti, Jerome I. Rotter, Noel K. Maclaren, Leslie J. Raffel, Lorenza Nisticò, Claudio Giovannini, Paolo Pozzilli, Glenys Thomson, Jin-Xiong She

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

Previous genome-wide mapping studies have provided suggestive linkage evidence for several novel susceptibility loci responsible for insulin-dependent diabetes mellitus (IDDM); however, the evidence was not sufficient to confirm the existence of these genes. We analyzed 265 Caucasian families with IDDM and report the first evidence that meets the standard for confirmed linkage for three susceptibility loci. The maximum LOD scores (MLS) were 3.9, 4.5 and 3.6 in our data set, and 5.0, 4.6 and 5.0 for our data combined with non-overlapping data from the literature, for IDDM4 on chromosome 11q13, IDDM5 on 6q25, and IDDM8 on 6q27, respectively. However, we could not confirm linkage for IDDM3 on 15q26 and IDDM7 on 2q31-q33, or linkage disequilibrium between D2S152 and IDDM7.

Original language	English (US)
Pages (from-to)	693-698
Number of pages	6
Journal	Human Molecular Genetics
Volume	5
Issue number	5
DOIs	https://doi.org/10.1093/hmg/5.5.693
State	Published - May 1996

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/hmg/5.5.693

Cite this

@article{b14e73e71dfd4858827a386507d8a604,

title = "Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8",

abstract = "Previous genome-wide mapping studies have provided suggestive linkage evidence for several novel susceptibility loci responsible for insulin-dependent diabetes mellitus (IDDM); however, the evidence was not sufficient to confirm the existence of these genes. We analyzed 265 Caucasian families with IDDM and report the first evidence that meets the standard for confirmed linkage for three susceptibility loci. The maximum LOD scores (MLS) were 3.9, 4.5 and 3.6 in our data set, and 5.0, 4.6 and 5.0 for our data combined with non-overlapping data from the literature, for IDDM4 on chromosome 11q13, IDDM5 on 6q25, and IDDM8 on 6q27, respectively. However, we could not confirm linkage for IDDM3 on 15q26 and IDDM7 on 2q31-q33, or linkage disequilibrium between D2S152 and IDDM7.",

author = "Luo, {De Fang} and Raffaella Buzzetti and Rotter, {Jerome I.} and Maclaren, {Noel K.} and Raffel, {Leslie J.} and Lorenza Nistic{\`o} and Claudio Giovannini and Paolo Pozzilli and Glenys Thomson and Jin-Xiong She",

year = "1996",

month = may,

doi = "10.1093/hmg/5.5.693",

language = "English (US)",

volume = "5",

pages = "693--698",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "5",

}

TY - JOUR

T1 - Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus

T2 - IDDM4, IDDM5 and IDDM8

AU - Luo, De Fang

AU - Buzzetti, Raffaella

AU - Rotter, Jerome I.

AU - Maclaren, Noel K.

AU - Raffel, Leslie J.

AU - Nisticò, Lorenza

AU - Giovannini, Claudio

AU - Pozzilli, Paolo

AU - Thomson, Glenys

AU - She, Jin-Xiong

PY - 1996/5

Y1 - 1996/5

N2 - Previous genome-wide mapping studies have provided suggestive linkage evidence for several novel susceptibility loci responsible for insulin-dependent diabetes mellitus (IDDM); however, the evidence was not sufficient to confirm the existence of these genes. We analyzed 265 Caucasian families with IDDM and report the first evidence that meets the standard for confirmed linkage for three susceptibility loci. The maximum LOD scores (MLS) were 3.9, 4.5 and 3.6 in our data set, and 5.0, 4.6 and 5.0 for our data combined with non-overlapping data from the literature, for IDDM4 on chromosome 11q13, IDDM5 on 6q25, and IDDM8 on 6q27, respectively. However, we could not confirm linkage for IDDM3 on 15q26 and IDDM7 on 2q31-q33, or linkage disequilibrium between D2S152 and IDDM7.

AB - Previous genome-wide mapping studies have provided suggestive linkage evidence for several novel susceptibility loci responsible for insulin-dependent diabetes mellitus (IDDM); however, the evidence was not sufficient to confirm the existence of these genes. We analyzed 265 Caucasian families with IDDM and report the first evidence that meets the standard for confirmed linkage for three susceptibility loci. The maximum LOD scores (MLS) were 3.9, 4.5 and 3.6 in our data set, and 5.0, 4.6 and 5.0 for our data combined with non-overlapping data from the literature, for IDDM4 on chromosome 11q13, IDDM5 on 6q25, and IDDM8 on 6q27, respectively. However, we could not confirm linkage for IDDM3 on 15q26 and IDDM7 on 2q31-q33, or linkage disequilibrium between D2S152 and IDDM7.

UR - http://www.scopus.com/inward/record.url?scp=9244244764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9244244764&partnerID=8YFLogxK

U2 - 10.1093/hmg/5.5.693

DO - 10.1093/hmg/5.5.693

M3 - Article

C2 - 8733139

AN - SCOPUS:9244244764

SN - 0964-6906

VL - 5

SP - 693

EP - 698

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 5

ER -

Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this