Conflicting roles of 20-HETE in hypertension and stroke

Shashank Shekhar, Kevin Varghese, Man Li, Letao Fan, George W. Booz, Richard J. Roman, Fan Fan

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Hypertension is the most common modifiable risk factor for stroke, and understanding the underlying mechanisms of hypertension and hypertension-related stroke is crucial. 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE), which plays an important role in vasoconstriction, autoregulation, endothelial dysfunction, angiogenesis, inflammation, and blood-brain barrier integrity, has been linked to hypertension and stroke. 20-HETE can promote hypertension by potentiating the vascular response to vasoconstrictors; it also can reduce blood pressure by inhibition of sodium transport in the kidney. The production of 20-HETE is elevated after the onset of both ischemic and hemorrhagic strokes; on the other hand, subjects with genetic variants in CYP4F2 and CYP4A11 that reduce 20-HETE production are more susceptible to stroke. This review summarizes recent genetic variants in CYP4F2, and CYP4A11 influencing 20-HETE production and discusses the role of 20-HETE in hypertension and the susceptibility to the onset, progression, and prognosis of ischemic and hemorrhagic strokes.

Original languageEnglish (US)
Article number4500
JournalInternational journal of molecular sciences
Issue number18
StatePublished - Sep 2 2019
Externally publishedYes


  • Angiogenesis
  • Blood-brain barrier
  • Cerebral autoregulation
  • Cytochrome P450
  • Endothelial dysfunction
  • Hypertension
  • Stroke
  • Vascular inflammation
  • Vascular remodeling

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'Conflicting roles of 20-HETE in hypertension and stroke'. Together they form a unique fingerprint.

Cite this