Conflicting roles of 20-HETE in hypertension and stroke

Shashank Shekhar, Kevin Varghese, Man Li, Letao Fan, George W. Booz, Richard J. Roman, Fan Fan

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Hypertension is the most common modifiable risk factor for stroke, and understanding the underlying mechanisms of hypertension and hypertension-related stroke is crucial. 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE), which plays an important role in vasoconstriction, autoregulation, endothelial dysfunction, angiogenesis, inflammation, and blood-brain barrier integrity, has been linked to hypertension and stroke. 20-HETE can promote hypertension by potentiating the vascular response to vasoconstrictors; it also can reduce blood pressure by inhibition of sodium transport in the kidney. The production of 20-HETE is elevated after the onset of both ischemic and hemorrhagic strokes; on the other hand, subjects with genetic variants in CYP4F2 and CYP4A11 that reduce 20-HETE production are more susceptible to stroke. This review summarizes recent genetic variants in CYP4F2, and CYP4A11 influencing 20-HETE production and discusses the role of 20-HETE in hypertension and the susceptibility to the onset, progression, and prognosis of ischemic and hemorrhagic strokes.

Original languageEnglish (US)
Article number4500
JournalInternational journal of molecular sciences
Volume20
Issue number18
DOIs
StatePublished - Sep 2 2019
Externally publishedYes

Keywords

  • Angiogenesis
  • Blood-brain barrier
  • Cerebral autoregulation
  • Cytochrome P450
  • Endothelial dysfunction
  • Hypertension
  • Stroke
  • Vascular inflammation
  • Vascular remodeling

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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