Abstract
Open-chain N-Cbz-protected-peptidoyl benzotriazolides are converted by a novel lactamization strategy using proline as a turn introducer into both symmetrical (5a-c and 11a-c) and unsymmetrical (19a-e) bis-2,5-diketopiperazines (bis-2,5-DKPs), previously recognized as difficult targets.
Original language | English (US) |
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Pages (from-to) | 8510-8523 |
Number of pages | 14 |
Journal | Journal of Organic Chemistry |
Volume | 78 |
Issue number | 17 |
DOIs | |
State | Published - Sep 6 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry