Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections

Yu Xuan Ma, Chen Yu Wang, Yuan Yuan Li, Jing Li, Qian Qian Wan, Ji Hua Chen, Franklin R. Tay, Li Na Niu

Research output: Contribution to journalReview articlepeer-review

157 Scopus citations


ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are among the most common opportunistic pathogens in nosocomial infections. ESKAPE pathogens distinguish themselves from normal ones by developing a high level of antibiotic resistance that involves multiple mechanisms. Contemporary therapeutic strategies which are potential options in combating ESKAPE bacteria need further investigation. Herein, a broad overview of the antimicrobial research on ESKAPE pathogens over the past five years is provided with prospective clinical applications.

Original languageEnglish (US)
Article number1901872
JournalAdvanced Science
Issue number1
StatePublished - Jan 1 2020


  • antimicrobial peptides
  • antiresistance
  • antivirulence
  • bacteriophages
  • nanodelivery strategies

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Chemical Engineering
  • General Materials Science
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • General Engineering
  • General Physics and Astronomy


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