TY - JOUR
T1 - Constipation
T2 - Evaluation and Treatment of Colonic and Anorectal Motility Disorders
AU - Rao, Satish S.C.
N1 - Funding Information:
This work was supported in part by grant DK57100-0441 from the National Institutes of Health and in part by the Department of Internal Medicine, University of Iowa Carver College of Medicine.
PY - 2007/9
Y1 - 2007/9
N2 - This article focuses on the colonic and anorectal motility disturbances that are associated with chronic constipation and their management. Functional chronic constipation consists of three overlapping subtypes: slow transit constipation, dyssynergic defecation, and irritable bowel syndrome with constipation. The Rome criteria may serve as a useful guide for making a clinical diagnosis of functional constipation. Today, an evidence-based approach can be used to treat patients with chronic constipation. The availability of specific drugs for the treatment of chronic constipation, such as tegaserod and lubiprostone, has enhanced the therapeutic armamentarium for managing these patients. Randomized controlled trials have also established the efficacy of biofeedback therapy in the treatment of dyssynergic defecation.
AB - This article focuses on the colonic and anorectal motility disturbances that are associated with chronic constipation and their management. Functional chronic constipation consists of three overlapping subtypes: slow transit constipation, dyssynergic defecation, and irritable bowel syndrome with constipation. The Rome criteria may serve as a useful guide for making a clinical diagnosis of functional constipation. Today, an evidence-based approach can be used to treat patients with chronic constipation. The availability of specific drugs for the treatment of chronic constipation, such as tegaserod and lubiprostone, has enhanced the therapeutic armamentarium for managing these patients. Randomized controlled trials have also established the efficacy of biofeedback therapy in the treatment of dyssynergic defecation.
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U2 - 10.1016/j.gtc.2007.07.013
DO - 10.1016/j.gtc.2007.07.013
M3 - Review article
C2 - 17950444
AN - SCOPUS:35348813332
SN - 0889-8553
VL - 36
SP - 687
EP - 711
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
IS - 3
ER -