Continued evolution of West Nile virus, Houston, Texas, USA, 2002-2012

Brian R. Mann; Allison R. McMullen; Daniele M. Swetnam; Vence Salvato; Martin Reyna; Hilda Guzman; Rudy Bueno; James A. Dennett; Robert B. Tesh; Alan D.T. Barrett

doi:10.3201/eid1909.130377

Continued evolution of West Nile virus, Houston, Texas, USA, 2002-2012

Brian R. Mann, Allison R. McMullen, Daniele M. Swetnam, Vence Salvato, Martin Reyna, Hilda Guzman, Rudy Bueno, James A. Dennett, Robert B. Tesh, Alan D.T. Barrett

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We investigated the genetics and evolution of West Nile virus (WNV) since initial detection in the United States in 1999 on the basis of continual surveillance studies in the Houston, Texas, USA, metropolitan area (Harris County) as a surrogate model for WNV evolution on a national scale. Full-length genomic sequencing of 14 novel 2010-2012 WNV isolates collected from resident birds in Harris County demonstrates emergence of 4 independent genetic groups distinct from historical strains circulating in the greater Houston region since 2002. Phylogenetic and geospatial analyses of the 2012 WNV isolates indicate closer genetic relationship with 2003-2006 Harris County isolates than more recent 2007-2011 isolates. Inferred monophyletic relationships of these groups with several 2006-2009 northeastern US isolates supports potential introduction of a novel WNV strain in Texas since 2010. These results emphasize the need to maintain WNV surveillance activities to better understand WNV transmission dynamics in the United States.

Original language	English (US)
Pages (from-to)	1418-1427
Number of pages	10
Journal	Emerging Infectious Diseases
Volume	19
Issue number	9
DOIs	https://doi.org/10.3201/eid1909.130377
State	Published - Sep 2013
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3201/eid1909.130377

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title = "Continued evolution of West Nile virus, Houston, Texas, USA, 2002-2012",

abstract = "We investigated the genetics and evolution of West Nile virus (WNV) since initial detection in the United States in 1999 on the basis of continual surveillance studies in the Houston, Texas, USA, metropolitan area (Harris County) as a surrogate model for WNV evolution on a national scale. Full-length genomic sequencing of 14 novel 2010-2012 WNV isolates collected from resident birds in Harris County demonstrates emergence of 4 independent genetic groups distinct from historical strains circulating in the greater Houston region since 2002. Phylogenetic and geospatial analyses of the 2012 WNV isolates indicate closer genetic relationship with 2003-2006 Harris County isolates than more recent 2007-2011 isolates. Inferred monophyletic relationships of these groups with several 2006-2009 northeastern US isolates supports potential introduction of a novel WNV strain in Texas since 2010. These results emphasize the need to maintain WNV surveillance activities to better understand WNV transmission dynamics in the United States.",

author = "Mann, {Brian R.} and McMullen, {Allison R.} and Swetnam, {Daniele M.} and Vence Salvato and Martin Reyna and Hilda Guzman and Rudy Bueno and Dennett, {James A.} and Tesh, {Robert B.} and Barrett, {Alan D.T.}",

year = "2013",

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doi = "10.3201/eid1909.130377",

language = "English (US)",

volume = "19",

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AU - Mann, Brian R.

AU - McMullen, Allison R.

AU - Swetnam, Daniele M.

AU - Salvato, Vence

AU - Reyna, Martin

AU - Guzman, Hilda

AU - Bueno, Rudy

AU - Dennett, James A.

AU - Tesh, Robert B.

AU - Barrett, Alan D.T.

PY - 2013/9

Y1 - 2013/9

N2 - We investigated the genetics and evolution of West Nile virus (WNV) since initial detection in the United States in 1999 on the basis of continual surveillance studies in the Houston, Texas, USA, metropolitan area (Harris County) as a surrogate model for WNV evolution on a national scale. Full-length genomic sequencing of 14 novel 2010-2012 WNV isolates collected from resident birds in Harris County demonstrates emergence of 4 independent genetic groups distinct from historical strains circulating in the greater Houston region since 2002. Phylogenetic and geospatial analyses of the 2012 WNV isolates indicate closer genetic relationship with 2003-2006 Harris County isolates than more recent 2007-2011 isolates. Inferred monophyletic relationships of these groups with several 2006-2009 northeastern US isolates supports potential introduction of a novel WNV strain in Texas since 2010. These results emphasize the need to maintain WNV surveillance activities to better understand WNV transmission dynamics in the United States.

AB - We investigated the genetics and evolution of West Nile virus (WNV) since initial detection in the United States in 1999 on the basis of continual surveillance studies in the Houston, Texas, USA, metropolitan area (Harris County) as a surrogate model for WNV evolution on a national scale. Full-length genomic sequencing of 14 novel 2010-2012 WNV isolates collected from resident birds in Harris County demonstrates emergence of 4 independent genetic groups distinct from historical strains circulating in the greater Houston region since 2002. Phylogenetic and geospatial analyses of the 2012 WNV isolates indicate closer genetic relationship with 2003-2006 Harris County isolates than more recent 2007-2011 isolates. Inferred monophyletic relationships of these groups with several 2006-2009 northeastern US isolates supports potential introduction of a novel WNV strain in Texas since 2010. These results emphasize the need to maintain WNV surveillance activities to better understand WNV transmission dynamics in the United States.

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Continued evolution of West Nile virus, Houston, Texas, USA, 2002-2012

Abstract

ASJC Scopus subject areas

UN SDGs

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