Abstract
This study characterizes contractions to ouabain and potassium-free solution in isolated vascular segments from two-kidney, one clip (2-K, 1C) hypertensive rats. Aorta, mesenteric artery, and vena cava from hypertensive rats were more sensitive (lower threshold) to ouabain than those from normotensive rats. Contractions of hypertensive vascular segments to potassium-free solution and to ouabain (10−3 mol/l) were faster than those in normotensive vessels. Monensin potentiated contractions to ouabain and increased the rate of force development to potassium-free solution to a greater extent in normotensive aortae than in hypertensive aortae. Amiloride, low sodium solution, verapamil and calcium-free solution depressed contractions to ouabain and potassium-free solution in both hypertensive and normotensive aortae. These observations demonstrate augmented responsiveness to ouabain and potassium-free solution in hypertensive blood vessels. Interventions which influence transmembrane sodium and calcium movements altered contractions to ouabain and potassium-free solution. The results are consistent with the hypothesis that vascular cells of hypertensive rats have enhanced sodium pump activity.
Original language | English (US) |
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Pages (from-to) | 161-171 |
Number of pages | 11 |
Journal | Journal of hypertension |
Volume | 5 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1987 |
Keywords
- Arteries
- Electrogenic sodium pump
- Vascular smooth muscle
- Veins
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine