Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin

Mykola Mamenko, Oleg Zaika, Nabila Boukelmoune, Eric Madden, Oleh Pochynyuk

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Kinins, such as Bradykinin (BK), are peptide hormones of the kallikrein-kinin system. Apart from being a vasodilator, BK also increases urinary sodium excretion to reduce systemic blood pressure. It is becoming appreciated that BK modulates function of the epithelial Na+ channel in the distal part of the renal nephron to affect tubular sodium reabsorption. In this chapter, we outline the molecular details, as well as discuss the physiological relevance of this regulation for the whole organism sodium homeostasis and setting chronic blood pressure.

Original languageEnglish (US)
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc.
Number of pages18
StatePublished - 2015
Externally publishedYes

Publication series

NameVitamins and Hormones
ISSN (Print)0083-6729


  • ACE inhibition
  • Blood pressure
  • Kidney
  • Natriuresis
  • Renal tubule
  • Salt sensitivity

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


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