TY - JOUR
T1 - Creating immune privilege
T2 - Active local suppression that benefits friends, but protects foes
AU - Mellor, Andrew L.
AU - Munn, David H.
PY - 2008/1
Y1 - 2008/1
N2 - Natural regulatory mechanisms prevent inappropriate immune activation to self and innocuous foreign antigens. Here, we adapt the notion of immune privilege, which was originally applied to transplanted tissues, to consider how antigenic tumour cells and chronic pathogens might exploit natural regulatory mechanisms to become non-immunogenic. This conceptual approach reveals new mechanistic perspectives that may help to explain the paradoxical persistence of tumours and chronic pathogens, and suggests new opportunities to improve immunotherapy to treat these chronic inflammatory diseases.
AB - Natural regulatory mechanisms prevent inappropriate immune activation to self and innocuous foreign antigens. Here, we adapt the notion of immune privilege, which was originally applied to transplanted tissues, to consider how antigenic tumour cells and chronic pathogens might exploit natural regulatory mechanisms to become non-immunogenic. This conceptual approach reveals new mechanistic perspectives that may help to explain the paradoxical persistence of tumours and chronic pathogens, and suggests new opportunities to improve immunotherapy to treat these chronic inflammatory diseases.
UR - http://www.scopus.com/inward/record.url?scp=37549061827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37549061827&partnerID=8YFLogxK
U2 - 10.1038/nri2233
DO - 10.1038/nri2233
M3 - Comment/debate
C2 - 18064049
AN - SCOPUS:37549061827
SN - 1474-1733
VL - 8
SP - 74
EP - 80
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 1
ER -