Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

N. Wagner, J. Lohler, E. J. Kunkel, K. Ley, E. Leung, G. Krissansen, K. Rajewsky, W. Muller

Research output: Contribution to journalArticlepeer-review

479 Scopus citations

Abstract

Immune defence against pathogens entering the gut is accomplished by lymphocytes in the gut-associated lymphoid tissue (GALT), a major compartment of the immune system. The GALT, comprising Peyer's patches, lamina propria lymphocytes and intra-epithelial lymphocytes of the intestine, is populated by lymphocytes that migrate there from the vasculature. Here we report that, in mice deficient for the β7 integrin subfamily of adhesion molecules, the formation of the GALT is severely impaired. This is probably due to a failure of β7(-/) lymphocytes to arrest and adhere to the vasculature at the site of transmigration into the GALT.

Original languageEnglish (US)
Pages (from-to)366-370
Number of pages5
JournalNature
Volume382
Issue number6589
DOIs
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • General

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