Cross-talk from β-adrenergic receptors modulates α2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin

Christopher Cottingham; Roujian Lu; Kai Jiao; Qin Wang

doi:10.1074/jbc.M113.469494

Cross-talk from β-adrenergic receptors modulates α_2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin

Christopher Cottingham
, Roujian Lu
, Kai Jiao
, Qin Wang

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background:Cross-talk between GPCRs is an important but undercharacterized mechanism regulating receptor responsiveness. Results:Co-activation of β and α₂ARs accelerates α_2AAR endocytosis in a PKA- and spinophilin-dependent fashion. Conclusion:βAR-mediated signaling modulates α_2AAR endocytosis via PKA-dependent disruption of α_2AAR/spinophilin interaction. Significance:Cross-talk from βto α2 ARs may have important implications in basal adrenergic tone and the pharmacology of commonly used adrenergic therapeutics.

Original language	English (US)
Pages (from-to)	29193-29205
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.469494
State	Published - Oct 4 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.469494

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title = "Cross-talk from β-adrenergic receptors modulates α2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin",

abstract = "Background:Cross-talk between GPCRs is an important but undercharacterized mechanism regulating receptor responsiveness. Results:Co-activation of β and α2ARs accelerates α2AAR endocytosis in a PKA- and spinophilin-dependent fashion. Conclusion:βAR-mediated signaling modulates α2AAR endocytosis via PKA-dependent disruption of α2AAR/spinophilin interaction. Significance:Cross-talk from βto α2 ARs may have important implications in basal adrenergic tone and the pharmacology of commonly used adrenergic therapeutics.",

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T1 - Cross-talk from β-adrenergic receptors modulates α2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin

AU - Cottingham, Christopher

AU - Lu, Roujian

AU - Jiao, Kai

AU - Wang, Qin

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Background:Cross-talk between GPCRs is an important but undercharacterized mechanism regulating receptor responsiveness. Results:Co-activation of β and α2ARs accelerates α2AAR endocytosis in a PKA- and spinophilin-dependent fashion. Conclusion:βAR-mediated signaling modulates α2AAR endocytosis via PKA-dependent disruption of α2AAR/spinophilin interaction. Significance:Cross-talk from βto α2 ARs may have important implications in basal adrenergic tone and the pharmacology of commonly used adrenergic therapeutics.

AB - Background:Cross-talk between GPCRs is an important but undercharacterized mechanism regulating receptor responsiveness. Results:Co-activation of β and α2ARs accelerates α2AAR endocytosis in a PKA- and spinophilin-dependent fashion. Conclusion:βAR-mediated signaling modulates α2AAR endocytosis via PKA-dependent disruption of α2AAR/spinophilin interaction. Significance:Cross-talk from βto α2 ARs may have important implications in basal adrenergic tone and the pharmacology of commonly used adrenergic therapeutics.

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 40

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Cross-talk from β-adrenergic receptors modulates α_2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin

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