TY - JOUR
T1 - Cryptococcal meningitis in pregnancy
AU - Stafford, Charles R.
AU - Fisher, John F.
AU - Fadel, Hossam E.
AU - Espinel-Ingroff, Ana V.
AU - Shadomy, Smith
AU - Hamby, Mary
PY - 1983/9
Y1 - 1983/9
N2 - Cryptococcal meningitis was diagnosed in a pregnant woman at 21 weeks' gestation. The availability of fetal tissues, blood, and amniotic fluid in such a patient receiving therapy with amphotericin B plus flucytosine afforded the opportunity to study the effects of the disease and therapeutic agents on the developing fetus. The amphotericin B concentration in amniotic fluid was 0.25 μg/ml and that of flucytosine was 168 μg/ml. The concentrations in cord blood were 0.3 μg/ml and 64.7 μg/ml, respectively. No evidence was found of amphotericin B or flucytosine toxicity in fetal tissues, although exposure of the fetus to these compounds was of brief duration.
AB - Cryptococcal meningitis was diagnosed in a pregnant woman at 21 weeks' gestation. The availability of fetal tissues, blood, and amniotic fluid in such a patient receiving therapy with amphotericin B plus flucytosine afforded the opportunity to study the effects of the disease and therapeutic agents on the developing fetus. The amphotericin B concentration in amniotic fluid was 0.25 μg/ml and that of flucytosine was 168 μg/ml. The concentrations in cord blood were 0.3 μg/ml and 64.7 μg/ml, respectively. No evidence was found of amphotericin B or flucytosine toxicity in fetal tissues, although exposure of the fetus to these compounds was of brief duration.
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M3 - Article
C2 - 6877708
AN - SCOPUS:0020576662
SN - 0029-7844
VL - 62
SP - 35S-37S
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 3
ER -