Cryptococcal meningitis in pregnancy

Charles R. Stafford, John Fremont Fisher, Hossam E. Fadel, Ana V. Espinel-Ingroff, Smith Shadomy, Mary Hamby

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Cryptococcal meningitis was diagnosed in a pregnant woman at 21 weeks' gestation. The availability of fetal tissues, blood, and amniotic fluid in such a patient receiving therapy with amphotericin B plus flucytosine afforded the opportunity to study the effects of the disease and therapeutic agents on the developing fetus. The amphotericin B concentration in amniotic fluid was 0.25 μg/ml and that of flucytosine was 168 μg/ml. The concentrations in cord blood were 0.3 μg/ml and 64.7 μg/ml, respectively. No evidence was found of amphotericin B or flucytosine toxicity in fetal tissues, although exposure of the fetus to these compounds was of brief duration.

Original languageEnglish (US)
Pages (from-to)35S-37S
JournalObstetrics and Gynecology
Issue number3
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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