TY - JOUR
T1 - Cutting edge
T2 - The orphan nuclear receptor Nr4a1 regulates CD8+ T cell expansion and effector function through direct repression of IRF4
AU - Nowyhed, Heba N.
AU - Huynh, Tridu R.
AU - Thomas, Graham D.
AU - Blatchley, Amy
AU - Hedrick, Catherine C.
N1 - Publisher Copyright:
Copyright © 2015 by The American Association of Immunologists, Inc.
PY - 2015/10/15
Y1 - 2015/10/15
N2 - The transcription factor IFN regulatory factor (IRF)4 was shown to play a crucial role in the protective CD8+ T cell response; however, regulation of IRF4 expression in CD8+ T cells remains unclear. In this article, we report a critical role for Nr4a1 in regulating the expansion, differentiation, and function of CD8+ T cells through direct transcriptional repression of Irf4. Without Nr4a1, the regulation of IRF4 is lost, driving an increase in Irf4 expression and, in turn, resulting in a faster rate of CD8 T cell proliferation and expansion. Nr4a1-deficient mice show increases in CD8 T cell effector responses with improved clearance of Listeria monocytogenes. Our data support a novel and critical role for Nr4a1 in the regulation of CD8+ T cell expansion and effector function through transcriptional repression of Irf4.
AB - The transcription factor IFN regulatory factor (IRF)4 was shown to play a crucial role in the protective CD8+ T cell response; however, regulation of IRF4 expression in CD8+ T cells remains unclear. In this article, we report a critical role for Nr4a1 in regulating the expansion, differentiation, and function of CD8+ T cells through direct transcriptional repression of Irf4. Without Nr4a1, the regulation of IRF4 is lost, driving an increase in Irf4 expression and, in turn, resulting in a faster rate of CD8 T cell proliferation and expansion. Nr4a1-deficient mice show increases in CD8 T cell effector responses with improved clearance of Listeria monocytogenes. Our data support a novel and critical role for Nr4a1 in the regulation of CD8+ T cell expansion and effector function through transcriptional repression of Irf4.
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U2 - 10.4049/jimmunol.1403027
DO - 10.4049/jimmunol.1403027
M3 - Article
C2 - 26363057
AN - SCOPUS:84943524061
SN - 0022-1767
VL - 195
SP - 3515
EP - 3519
JO - Journal of Immunology
JF - Journal of Immunology
IS - 8
ER -