CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity

K. Mark Ansel; Ruth B.S. Harris; Jason G. Cyster

doi:10.1016/S1074-7613(01)00257-6

CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity

K. Mark Ansel, Ruth B.S. Harris, Jason G. Cyster

Research output: Contribution to journal › Article › peer-review

424 Scopus citations

Abstract

B1 cells are a predominant cell type in body cavities and an important source of natural antibody. Here we report that in mice lacking the chemokine, CXCL13, B1 cells are deficient in peritoneal and pleural cavities but not in spleen. CXCL13 is produced by cells in the omentum and by peritoneal macrophages, and in adoptive transfers, B1 cells home to the omentum and the peritoneal cavity in a CXCL13-dependent manner. CXCL13^-/- mice are deficient in preexisting phosphorylcholine (PC)-specific antibodies and in their ability to mount an anti-PC response to peritoneal streptococcal antigen. These findings provide insight into the mechanism of B1 cell homing and establish a critical role for B1 cell compartmentalization in the production of natural antibodies and for body cavity immunity.

Original language	English (US)
Pages (from-to)	67-76
Number of pages	10
Journal	Immunity
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/S1074-7613(01)00257-6
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1074-7613(01)00257-6

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@article{355de020c35d46709a02ede859359b5f,

title = "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity",

abstract = "B1 cells are a predominant cell type in body cavities and an important source of natural antibody. Here we report that in mice lacking the chemokine, CXCL13, B1 cells are deficient in peritoneal and pleural cavities but not in spleen. CXCL13 is produced by cells in the omentum and by peritoneal macrophages, and in adoptive transfers, B1 cells home to the omentum and the peritoneal cavity in a CXCL13-dependent manner. CXCL13-/- mice are deficient in preexisting phosphorylcholine (PC)-specific antibodies and in their ability to mount an anti-PC response to peritoneal streptococcal antigen. These findings provide insight into the mechanism of B1 cell homing and establish a critical role for B1 cell compartmentalization in the production of natural antibodies and for body cavity immunity.",

author = "Ansel, {K. Mark} and Harris, {Ruth B.S.} and Cyster, {Jason G.}",

note = "Funding Information: We thank John Kearney and Flavius Martin for reagents and helpful comments, Cliff McArthur for FACS sorting, and Paul Hyman, Tiffany Mitchell, and Afshin Bidgol for technical assistance. K.M.A. is a predoctoral fellow, and J.G.C. an Assistant Investigator of the HHMI. This work was supported by NIH grant AI45073.",

year = "2002",

doi = "10.1016/S1074-7613(01)00257-6",

language = "English (US)",

volume = "16",

pages = "67--76",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "1",

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T1 - CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity

AU - Ansel, K. Mark

AU - Harris, Ruth B.S.

AU - Cyster, Jason G.

N1 - Funding Information: We thank John Kearney and Flavius Martin for reagents and helpful comments, Cliff McArthur for FACS sorting, and Paul Hyman, Tiffany Mitchell, and Afshin Bidgol for technical assistance. K.M.A. is a predoctoral fellow, and J.G.C. an Assistant Investigator of the HHMI. This work was supported by NIH grant AI45073.

PY - 2002

Y1 - 2002

N2 - B1 cells are a predominant cell type in body cavities and an important source of natural antibody. Here we report that in mice lacking the chemokine, CXCL13, B1 cells are deficient in peritoneal and pleural cavities but not in spleen. CXCL13 is produced by cells in the omentum and by peritoneal macrophages, and in adoptive transfers, B1 cells home to the omentum and the peritoneal cavity in a CXCL13-dependent manner. CXCL13-/- mice are deficient in preexisting phosphorylcholine (PC)-specific antibodies and in their ability to mount an anti-PC response to peritoneal streptococcal antigen. These findings provide insight into the mechanism of B1 cell homing and establish a critical role for B1 cell compartmentalization in the production of natural antibodies and for body cavity immunity.

AB - B1 cells are a predominant cell type in body cavities and an important source of natural antibody. Here we report that in mice lacking the chemokine, CXCL13, B1 cells are deficient in peritoneal and pleural cavities but not in spleen. CXCL13 is produced by cells in the omentum and by peritoneal macrophages, and in adoptive transfers, B1 cells home to the omentum and the peritoneal cavity in a CXCL13-dependent manner. CXCL13-/- mice are deficient in preexisting phosphorylcholine (PC)-specific antibodies and in their ability to mount an anti-PC response to peritoneal streptococcal antigen. These findings provide insight into the mechanism of B1 cell homing and establish a critical role for B1 cell compartmentalization in the production of natural antibodies and for body cavity immunity.

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U2 - 10.1016/S1074-7613(01)00257-6

DO - 10.1016/S1074-7613(01)00257-6

M3 - Article

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AN - SCOPUS:0036169940

SN - 1074-7613

VL - 16

SP - 67

EP - 76

JO - Immunity

JF - Immunity

IS - 1

ER -

CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity

Abstract

ASJC Scopus subject areas

UN SDGs

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