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Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients

  • T. Murayama
  • , F. Jisaki
  • , M. Ayata
  • , D. Sakamuro
  • , T. Hironaka
  • , K. Hirai
  • , N. Tsuchiya
  • , K. Ito
  • , T. Furukawa

Research output: Contribution to journalArticlepeer-review

Abstract

Synovial fluid from 20 patients with rheumatoid arthritis was analyzed to detect human cytomegalovirus (CMV) genomic material using polymerase chain reaction. Of 20 samples tested, 9 were positive for CMV by either ethidium bromide staining or Southern blotting. In contrast, CMV was detected in only 2 of 18 control patients with osteoarthritis. These results suggest an etiologic relationship between CMV and rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalClinical and Experimental Rheumatology
Volume10
Issue number2
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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