Cytoskeletal regulation of nitric oxide synthase

Yunchao Su; Dmitry Kondrikov; Edward R. Block

doi:10.1385/CBB:43:3:439

Cytoskeletal regulation of nitric oxide synthase

Yunchao Su, Dmitry Kondrikov, Edward R. Block

Pharmacology and Toxicology

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

The three isoforms of nitric oxide synthase (NOS) - endothelial NOS (eNOS), inducible NOS (iNOS), and neural NOS (nNOS) - colocalize with the cytoskeleton including actin microfilaments, microtubules, and intermediate filaments directly or indirectly. These colocalizations enable optimal nitric oxide production and help NOS exert their functions. The reorganization of cytoskeletal polymerization state induced by extracellular stimuli such as shear stress, hypoxia, and drugs regulates eNOS, nNOS, and iNOS. Alterations of nitric oxide production caused by cytoskeletal reorganization play an important role in physiological and pathophysiological conditions. This review focuses on recent data regarding the regulation of NOS by the cytoskeleton at transcriptional, posttranscriptional, and posttranslational levels.

Original language	English (US)
Pages (from-to)	439-449
Number of pages	11
Journal	Cell Biochemistry and Biophysics
Volume	43
Issue number	3
DOIs	https://doi.org/10.1385/CBB:43:3:439
State	Published - Nov 2005

Keywords

Actin
Endothelium
Intermediate filaments
Microtubules
Transcription

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

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10.1385/CBB:43:3:439

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title = "Cytoskeletal regulation of nitric oxide synthase",

abstract = "The three isoforms of nitric oxide synthase (NOS) - endothelial NOS (eNOS), inducible NOS (iNOS), and neural NOS (nNOS) - colocalize with the cytoskeleton including actin microfilaments, microtubules, and intermediate filaments directly or indirectly. These colocalizations enable optimal nitric oxide production and help NOS exert their functions. The reorganization of cytoskeletal polymerization state induced by extracellular stimuli such as shear stress, hypoxia, and drugs regulates eNOS, nNOS, and iNOS. Alterations of nitric oxide production caused by cytoskeletal reorganization play an important role in physiological and pathophysiological conditions. This review focuses on recent data regarding the regulation of NOS by the cytoskeleton at transcriptional, posttranscriptional, and posttranslational levels.",

keywords = "Actin, Endothelium, Intermediate filaments, Microtubules, Transcription",

author = "Yunchao Su and Dmitry Kondrikov and Block, {Edward R.}",

note = "Funding Information: This work was supported by the Medical Research Service of the Department of Veterans Affairs, National Institutes of Health grants HL52136 and HL67951, American Heart Association Florida Affiliate grant 0130450B, American Lung Association Grant RG-006-N, and Flight Attendant Medical Research Institute grant 032040.",

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doi = "10.1385/CBB:43:3:439",

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AU - Su, Yunchao

AU - Kondrikov, Dmitry

AU - Block, Edward R.

N1 - Funding Information: This work was supported by the Medical Research Service of the Department of Veterans Affairs, National Institutes of Health grants HL52136 and HL67951, American Heart Association Florida Affiliate grant 0130450B, American Lung Association Grant RG-006-N, and Flight Attendant Medical Research Institute grant 032040.

PY - 2005/11

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N2 - The three isoforms of nitric oxide synthase (NOS) - endothelial NOS (eNOS), inducible NOS (iNOS), and neural NOS (nNOS) - colocalize with the cytoskeleton including actin microfilaments, microtubules, and intermediate filaments directly or indirectly. These colocalizations enable optimal nitric oxide production and help NOS exert their functions. The reorganization of cytoskeletal polymerization state induced by extracellular stimuli such as shear stress, hypoxia, and drugs regulates eNOS, nNOS, and iNOS. Alterations of nitric oxide production caused by cytoskeletal reorganization play an important role in physiological and pathophysiological conditions. This review focuses on recent data regarding the regulation of NOS by the cytoskeleton at transcriptional, posttranscriptional, and posttranslational levels.

AB - The three isoforms of nitric oxide synthase (NOS) - endothelial NOS (eNOS), inducible NOS (iNOS), and neural NOS (nNOS) - colocalize with the cytoskeleton including actin microfilaments, microtubules, and intermediate filaments directly or indirectly. These colocalizations enable optimal nitric oxide production and help NOS exert their functions. The reorganization of cytoskeletal polymerization state induced by extracellular stimuli such as shear stress, hypoxia, and drugs regulates eNOS, nNOS, and iNOS. Alterations of nitric oxide production caused by cytoskeletal reorganization play an important role in physiological and pathophysiological conditions. This review focuses on recent data regarding the regulation of NOS by the cytoskeleton at transcriptional, posttranscriptional, and posttranslational levels.

KW - Actin

KW - Endothelium

KW - Intermediate filaments

KW - Microtubules

KW - Transcription

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Cytoskeletal regulation of nitric oxide synthase

Abstract

Keywords

ASJC Scopus subject areas

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