TY - JOUR
T1 - D-penicillamine-induced myasthenia gravis
T2 - Diagnosis obscured by coexisting chronic obstructive pulmonary disease
AU - Adelman, H. M.
AU - Winters, P. R.
AU - Mahan, C. S.
AU - Wallach, P. M.
PY - 1995
Y1 - 1995
N2 - D-penicillamine, a drug used to treat rheumatoid arthritis, Wilson's disease, and cystinuria, can cause myasthenia gravis. Fortunately, the myasthenia typically resolves after discontinuation of the drug. The diagnosis may be missed if weakness is blamed on a patient's underlying disease(s), in particular, rheumatoid arthritis. Reported here are the cases of two patients with chronic obstructive lung disease who were taking D- penicillamine for rheumatoid arthritis, then experienced increasing respiratory failure. At first, their problem seemed to stem from chronic lung disease, but further evaluation revealed the cause of the hypoventilation to be D-penicillamine-induced myasthenia gravis.
AB - D-penicillamine, a drug used to treat rheumatoid arthritis, Wilson's disease, and cystinuria, can cause myasthenia gravis. Fortunately, the myasthenia typically resolves after discontinuation of the drug. The diagnosis may be missed if weakness is blamed on a patient's underlying disease(s), in particular, rheumatoid arthritis. Reported here are the cases of two patients with chronic obstructive lung disease who were taking D- penicillamine for rheumatoid arthritis, then experienced increasing respiratory failure. At first, their problem seemed to stem from chronic lung disease, but further evaluation revealed the cause of the hypoventilation to be D-penicillamine-induced myasthenia gravis.
KW - D-penicillamine, Adverse effects
KW - Lung diseases
KW - Myasthenia gravis
KW - Obstructive
KW - Respiratory insufficiency
UR - http://www.scopus.com/inward/record.url?scp=0028951379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028951379&partnerID=8YFLogxK
U2 - 10.1097/00000441-199504000-00001
DO - 10.1097/00000441-199504000-00001
M3 - Article
C2 - 7900739
AN - SCOPUS:0028951379
SN - 0002-9629
VL - 309
SP - 191
EP - 193
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 4
ER -