TY - JOUR
T1 - Decreased penile erection in doca-salt and stroke prone-spontaneously hypertensive rats
AU - Chitaley, K.
AU - Webb, R. C.
AU - Dorrance, A. M.
AU - Mills, T. M.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health (NIH HL18575), American Heart Association (AHA 9960075V) Southeast Affiliate, and American Health Assistance Foundation (AHAF H2000011). K Chitaley is the recipient of support from a NIH training grant for Systems and Integrative Physiology (2-T32-GM0832211). Dr AM Dorrance is the recipient of an American Heart Association Scientist Development Grant 0130364N. Y-27632 was a gracious gift from Welfide Corporation (Osaka, Japan).
PY - 2001/12
Y1 - 2001/12
N2 - Numerous etiological studies have established a positive clinical association between hypertension and erectile dysfunction. However, to date, the mechanism underlying this dysfunction remains to be established. In this study, we demonstrate the presence of erectile dysfunction in two rat models of hypertension, and hypothesize that increased vasoconstrictor signaling via Rho-kinase contributes to the decreased erectile response. We found deoxycorticosterone-salt and stroke prone-spontaneously hypertensive rats to exhibit a decreased erectile response, recorded as intracavernosal pressure/mean arterial pressure (ICP/MAP) upon electrical stimulation of the major pelvic ganglion. As previously shown, inhibition of Rho-kinase activity by intracavernosal injection of the selective inhibitor, Y-27632, resulted in an increase in ICP/MAP. However, Y-27632 was significantly less effective at increasing ICP/MAP in the hypertensive as compared to normotensive rats. Additionally, intracavernosal injection of Y-27632 potentiated the voltage-stimulated increase in ICP/MAP in both hypertensive and normotensive rats, but was less effective at potentiating the voltage-mediated erectile response in the hypertensive rats. Altogether, our data demonstrate a decreased erectile response in a mineralocorticoid and genetic model of hypertension, and suggest the role of increased cell signaling by Rho-kinase in the vasoconstrictor activity of erectile dysfunction associated with hypertension.
AB - Numerous etiological studies have established a positive clinical association between hypertension and erectile dysfunction. However, to date, the mechanism underlying this dysfunction remains to be established. In this study, we demonstrate the presence of erectile dysfunction in two rat models of hypertension, and hypothesize that increased vasoconstrictor signaling via Rho-kinase contributes to the decreased erectile response. We found deoxycorticosterone-salt and stroke prone-spontaneously hypertensive rats to exhibit a decreased erectile response, recorded as intracavernosal pressure/mean arterial pressure (ICP/MAP) upon electrical stimulation of the major pelvic ganglion. As previously shown, inhibition of Rho-kinase activity by intracavernosal injection of the selective inhibitor, Y-27632, resulted in an increase in ICP/MAP. However, Y-27632 was significantly less effective at increasing ICP/MAP in the hypertensive as compared to normotensive rats. Additionally, intracavernosal injection of Y-27632 potentiated the voltage-stimulated increase in ICP/MAP in both hypertensive and normotensive rats, but was less effective at potentiating the voltage-mediated erectile response in the hypertensive rats. Altogether, our data demonstrate a decreased erectile response in a mineralocorticoid and genetic model of hypertension, and suggest the role of increased cell signaling by Rho-kinase in the vasoconstrictor activity of erectile dysfunction associated with hypertension.
KW - Deoxycorticosterone
KW - Erectile dysfunction
KW - Hypertension
KW - Stroke prone SHR
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U2 - 10.1038/sj.ijir.3900773
DO - 10.1038/sj.ijir.3900773
M3 - Article
C2 - 11781742
AN - SCOPUS:0035674453
SN - 0955-9930
VL - 13
SP - S16-S20
JO - International journal of impotence research
JF - International journal of impotence research
ER -