Abstract
The goal of cancer therapy is to eliminate the cancer and/or to arrest further growth while decreasing normal tissue toxicity, i.e. to increase the therapeutic ratio. This review focuses on a group of therapeutics that are either (1) directly stimulated by radiation to produce either directly or indirectly cytotoxic agents (i.e. genes under the control of a radiation inducible promoter that produce a cytotoxic protein or an enzyme that converts a prodrug to an active form, respectively); (2) auger-electron emitting radiolabelled oligonucleotides, antibodies, nucleotide analogues, or other small molecules that are internalized; (3) radiation inducible genes that produce a ligand or transporter (or the like) which then can be targeted by cytotoxic agents (e.g. radiolabelled substance). We have termed this group of therapeutics radiogenic therapy.
Original language | English (US) |
---|---|
Pages (from-to) | 289-294 |
Number of pages | 6 |
Journal | Cancer Treatment Reviews |
Volume | 27 |
Issue number | 5 |
DOIs | |
State | Published - Jan 1 2001 |
Keywords
- Antibody
- Cancer
- Genes
- Radiation
- Somatostatin
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging