Definition epidemiology natural history and clinical phases

Vamsi Kota, Kavita Natarajan

Research output: Chapter in Book/Report/Conference proceedingChapter


Chronic Myeloid Leukemia (CML) is a relatively rare hematological malignancy with just over 5000 cases diagnosed annually in the United States. It is a disease found in the elderly with a median age in the 60s and it is rarely seen in children. It has the characteristic Philadelphia chromosome first identified in 1960. This has lead to tremendous revolution in the field of CML with the past 10 years leading to spectacular improvement in outcomes in this disease. The natural history of the disease has changed dramatically with the addition of the tyrosine kinase inhibitors and most of the information about the course of the disease is from studies prior to the introduction of the tyrosine kinases. Most of the patients present with chronic phase with progression to the blast phase eventually with differentiation arrest.

Original languageEnglish (US)
Title of host publicationChronic Myeloid Leukemia
Subtitle of host publicationFrom Daily Management to Complicated Issues
PublisherNova Science Publishers, Inc.
Number of pages8
ISBN (Electronic)9781629489926
ISBN (Print)9781629489711
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • General Medicine


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