Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated

Sergei A. Kirov; Kristen M. Harris

doi:10.1038/13178

Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated

Sergei A. Kirov, Kristen M. Harris

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

Abstract

Dendrites of CA1 pyramidal neurons in mature rat hippocampal slices were exposed to different levels of synaptic activation. In some slices, synaptic transmission was blocked with glutamate receptor antagonists, sodium and calcium channel blockers and/or a nominally calcium-free medium with high magnesium. In other slices, synapses were activated with low-frequency control stimulation or repeated tetanic stimulation. In slices with blocked synaptic transmission, dendrites were spinier than in either of the activated states. Thus, mature neurons can increase their numbers of spines, possibly compensating for lost synaptic activity.

Original language	English (US)
Pages (from-to)	878-883
Number of pages	6
Journal	Nature Neuroscience
Volume	2
Issue number	10
DOIs	https://doi.org/10.1038/13178
State	Published - Oct 1999
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1038/13178

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title = "Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated",

abstract = "Dendrites of CA1 pyramidal neurons in mature rat hippocampal slices were exposed to different levels of synaptic activation. In some slices, synaptic transmission was blocked with glutamate receptor antagonists, sodium and calcium channel blockers and/or a nominally calcium-free medium with high magnesium. In other slices, synapses were activated with low-frequency control stimulation or repeated tetanic stimulation. In slices with blocked synaptic transmission, dendrites were spinier than in either of the activated states. Thus, mature neurons can increase their numbers of spines, possibly compensating for lost synaptic activity.",

author = "Kirov, {Sergei A.} and Harris, {Kristen M.}",

note = "Funding Information: We thank J. Fiala for improving IGL Trace for use with confocal microscopy and for his input on this work. We also thank M. Feinberg and A. Goddard for technical support. This work was supported by NIH grants NS21184, NS33574, MH/DA57351, which is funded jointly by NIMH, NIDA, NASA (K.M.H) and the Mental Retardation Research Center grant P30-HD18655 to Joseph Volpe.",

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doi = "10.1038/13178",

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Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated

Abstract

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