Deoxyribonucleic acid analysis of the zinc finger Y gene in 45,X/46,XY subjects

L. Plouffe, A. Behzadian, S. P. Tho, P. G. McDonough

Research output: Contribution to journalArticlepeer-review


The deoxyribonucleic acid from nine subjects with a 45,X/46,XY karyotype with a cytogenetically intact Y chromosome and phenotypically presenting with bilateral streak gonads, streak and testis, or bilateral scrotal testes along with a control male and female were analyzed for the presence of the zinc finger Y sequence through the molecular probe pDP1007. This particular probe is thought to constitute part of the putative testicular-determining factor gene. All the study subjects demonstrated the presence of zinc finger Y. Laser densitometry studies confirmed a correlation between the intensity of the zinc finger Y band and the percentage of Y cell lines. This study supports the fact that individuals with mixed gonadal dysgenesis and cytogenetically intact Y chromosomes will tend to have intact zinc finger Y sequences.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalFertility and sterility
Issue number2
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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