TY - JOUR
T1 - Depsidone and diaryl ether derivatives from the fungus Corynespora cassiicola, an endophyte of Gongronema latifolium
AU - Okoye, Festus Basden C.
AU - Lu, Su
AU - Nworu, Chukwuemeka S.
AU - Esimone, Charles O.
AU - Proksch, Peter
AU - Chadli, Ahmed
AU - Debbab, Abdessamad
N1 - Funding Information:
Dr. F.B.C.O wishes to thank the Alexander von Humboldt Foundation for the postdoctoral fellowship. This study was supported by Grants of the BMBF awarded to P.P. and A.D.
PY - 2013/8/7
Y1 - 2013/8/7
N2 - Chemical investigation of the ethyl acetate extract of Corynespora cassiicola, an endophytic fungus of Gongronema latifolium, afforded three new secondary metabolites, including corynesidone D (1), corynether B (2) and corynether lactone A (3), together with four known derivatives. The structures of the new compounds were deduced on the basis of 1D- and 2D-dimensional NMR spectroscopy as well as by high resolution mass spectrometry. Compounds 1 and 4-6 were tested for their ability to modulate the chaperoning activity of the Hsp90 chaperoning machine in vitro using 17-allylamino-demethoxygeldamycin (17-AAG) as a positive control. Unfortunately, no effect on the Hsp90 chaperoning machine has been observed.
AB - Chemical investigation of the ethyl acetate extract of Corynespora cassiicola, an endophytic fungus of Gongronema latifolium, afforded three new secondary metabolites, including corynesidone D (1), corynether B (2) and corynether lactone A (3), together with four known derivatives. The structures of the new compounds were deduced on the basis of 1D- and 2D-dimensional NMR spectroscopy as well as by high resolution mass spectrometry. Compounds 1 and 4-6 were tested for their ability to modulate the chaperoning activity of the Hsp90 chaperoning machine in vitro using 17-allylamino-demethoxygeldamycin (17-AAG) as a positive control. Unfortunately, no effect on the Hsp90 chaperoning machine has been observed.
KW - Corynespora cassiicola
KW - Endophytes
KW - Heat shock protein 90 (Hsp90)
KW - Structure elucidation
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U2 - 10.1016/j.tetlet.2013.05.117
DO - 10.1016/j.tetlet.2013.05.117
M3 - Article
AN - SCOPUS:84879838664
SN - 0040-4039
VL - 54
SP - 4210
EP - 4214
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 32
ER -