TY - JOUR
T1 - Development of a cumulative exposure index (CEI) for manganese and comparison with bone manganese and other biomarkers of manganese exposure
AU - Rolle-Mcfarland, Danelle
AU - Liu, Yingzi
AU - Zhou, Jieqiong
AU - Mostafaei, Farshad
AU - Zhou, Yuanzhong
AU - Li, Yan
AU - Fan, Quiyan
AU - Zheng, Wei
AU - Nie, Linda H.
AU - Wells, Ellen M.
N1 - Funding Information:
Funding: This research was funded by the National Natural Science Foundation of China [81760582 (Y.L.)]; the Natural Science Foundation of Guizhou Provincial Scientific and Technology Department [2017-1215 (Y.L.)]; International Scientific and Technology cooperation project of Guizhou Province [G2014-7012 (Y.L. and W.Z.)]; Innovative talent team training project of Zunyi City [2015-42 (Y.L.)]; U.S. Centers for Disease Control and Prevention/NIOSH [R-21 OH010700 (L.H.N.)]; U.S NIH/NIEHS [R01-ES008146 (W.Z.)] and [RO1-ES027078 (W.Z.)].
Funding Information:
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA; Danelle.Rolle-Mcfarland@moffitt.org (D.R.-M.); yliu@wkhs.com (Y.L.); jieqiong.zhou@yale.edu (J.Z.); fmostafaei@mcw.edu (F.M.); wzheng@purdue.edu (W.Z.); hnie@purdue.edu (L.H.N.) Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA Willis-Knighton Cancer Center, Shreveport, LA 71103, USA Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA School of Public Health, Zunyi Medical University, Zunyi 563003, Guizhou, China; zhouyuanzhong@163.com (Y.Z.); liyan067321@sina.com (Y.L.) Zunyi Medical and Pharmaceutical College, Zunyi 563003, Guizhou, China; fanqy@zunyiyizhuan.cn Correspondence: wells54@purdue.edu; Tel.: +1-765-496-3535 These authors contributed equally to this work.
Funding Information:
This research was funded by the National Natural Science Foundation of China [81760582 (Y.L.)]; the Natural Science Foundation of Guizhou Provincial Scientific and Technology Department [2017-1215 (Y.L.)]; International Scientific and Technology cooperation project of Guizhou Province [G2014-7012 (Y.L. and W.Z.)]; Innovative talent team training project of Zunyi City [2015-42 (Y.L.)]; U.S. Centers for Disease Control and Prevention/NIOSH [R-21 OH010700 (L.H.N.)]; U.S NIH/NIEHS [R01-ES008146 (W.Z.)] and [RO1-ES027078 (W.Z.)].
Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/7
Y1 - 2018/7
N2 - Manganese (Mn) exposure can result in parkinsonism. However, understanding of manganese neurotoxicity has been limited by the lack of a cumulative Mn biomarker. Therefore, the current goal was to develop Mn cumulative exposure indices (MnCEI), an established method to estimate cumulative exposure, and determine associations of MnCEI with blood Mn (BMn), fingernail Mn (FMn), and bone Mn (BnMn). We completed a cross-sectional study of 60 male Chinese workers. Self-reported occupational history was used to create two MnCEIs reflecting the previous 16 years (MnCEI16) and total work history (MnCEITOT). An in vivo neutron activation analysis system was used to quantify BnMn. BMn and FMn were measured using ICP-MS. Mean (standard deviation) MnCEITOT and MnCEI16 were 37.5 (22.0) and 25.0 (11.3), respectively. Median (interquartile range) BMn, FMn, and BnMn were 14.1 (4.0) μg/L, 13.5 (58.5) μg/g, and 2.6 (7.2) μg/g dry bone, respectively. MnCEI16 was significantly correlated with FMn (Spearman’s r = 0.44; p = 0.02), BnMn (r = 0.44; p 7lt; 0.01), and MnCEITOT (r = 0.44; p < 0.01). In adjusted regression models, MnCEI16 was significantly associated with BnMn (β = 0.03; 95% confidence interval = 0.001, 0.05); no other biomarkers were associated with MnCEI. This suggests BnMn may be a useful biomarker of the previous 16 years of Mn exposure, but larger studies are recommended.
AB - Manganese (Mn) exposure can result in parkinsonism. However, understanding of manganese neurotoxicity has been limited by the lack of a cumulative Mn biomarker. Therefore, the current goal was to develop Mn cumulative exposure indices (MnCEI), an established method to estimate cumulative exposure, and determine associations of MnCEI with blood Mn (BMn), fingernail Mn (FMn), and bone Mn (BnMn). We completed a cross-sectional study of 60 male Chinese workers. Self-reported occupational history was used to create two MnCEIs reflecting the previous 16 years (MnCEI16) and total work history (MnCEITOT). An in vivo neutron activation analysis system was used to quantify BnMn. BMn and FMn were measured using ICP-MS. Mean (standard deviation) MnCEITOT and MnCEI16 were 37.5 (22.0) and 25.0 (11.3), respectively. Median (interquartile range) BMn, FMn, and BnMn were 14.1 (4.0) μg/L, 13.5 (58.5) μg/g, and 2.6 (7.2) μg/g dry bone, respectively. MnCEI16 was significantly correlated with FMn (Spearman’s r = 0.44; p = 0.02), BnMn (r = 0.44; p 7lt; 0.01), and MnCEITOT (r = 0.44; p < 0.01). In adjusted regression models, MnCEI16 was significantly associated with BnMn (β = 0.03; 95% confidence interval = 0.001, 0.05); no other biomarkers were associated with MnCEI. This suggests BnMn may be a useful biomarker of the previous 16 years of Mn exposure, but larger studies are recommended.
KW - Biomarkers
KW - Blood manganese
KW - Bone manganese
KW - Cumulative exposure index
KW - Fingernail manganese
KW - In vivo neutron activation analysis
KW - Manganese
UR - http://www.scopus.com/inward/record.url?scp=85056276183&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056276183&partnerID=8YFLogxK
U2 - 10.3390/ijerph15071341
DO - 10.3390/ijerph15071341
M3 - Article
C2 - 29949870
AN - SCOPUS:85056276183
SN - 1661-7827
VL - 15
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 7
M1 - 1341
ER -
