Development of monocytes, macrophages, and dendritic cells

Frederic Geissmann, Markus G. Manz, Steffen Jung, Michael H. Sieweke, Miriam Merad, Klaus Ley

Research output: Contribution to journalReview articlepeer-review

1127 Scopus citations


Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and tolerance. Recent in vivo experimental approaches in the mouse have unveiled new aspects of the developmental and lineage relationships among these cell populations. Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated.

Original languageEnglish (US)
Pages (from-to)656-661
Number of pages6
Issue number5966
StatePublished - Feb 5 2010
Externally publishedYes

ASJC Scopus subject areas

  • General


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