Differential effects of left versus right seizure focus on human hippocampal evoked responses

Kimford J. Meador; David W. Loring; Brian B. Gallagher; Don W. King; Anthony M Murro; Elaine E. Thompson; Gregory P Lee; Herman F. Flanigin; Joseph R. Smith; Jennifer Dushku; Harry Davis

doi:10.3109/00207459208999792

Differential effects of left versus right seizure focus on human hippocampal evoked responses

Kimford J. Meador, David W. Loring, Brian B. Gallagher, Don W. King, Anthony M Murro, Elaine E. Thompson, Gregory P Lee, Herman F. Flanigin, Joseph R. Smith, Jennifer Dushku, Harry Davis

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Hippocampal evoked potentials were recorded using the P3 tonal oddball paradigm in 30 patients with unilateral temporal lobe seizure focus. Spectral power of the evoked potentials was decreased on the side of seizure focus, but this reduction was much greater when the focus was on the left. The effect of left/right focus does not appear to be due to group differences in age, sex, seizure duration, or operative pathology. Remote or finer left/right structural differences or differential left/right hippocampal processing for the sequential tonal task are possible explanations.

Original language	English (US)
Pages (from-to)	87-91
Number of pages	5
Journal	International Journal of Neuroscience
Volume	66
Issue number	1-2
DOIs	https://doi.org/10.3109/00207459208999792
State	Published - 1992

Keywords

Epilepsy
Evoked potentials
Hippocampus

ASJC Scopus subject areas

General Neuroscience

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10.3109/00207459208999792

Cite this

@article{ee6faf809a3b403f9b243ec01815259b,

title = "Differential effects of left versus right seizure focus on human hippocampal evoked responses",

abstract = "Hippocampal evoked potentials were recorded using the P3 tonal oddball paradigm in 30 patients with unilateral temporal lobe seizure focus. Spectral power of the evoked potentials was decreased on the side of seizure focus, but this reduction was much greater when the focus was on the left. The effect of left/right focus does not appear to be due to group differences in age, sex, seizure duration, or operative pathology. Remote or finer left/right structural differences or differential left/right hippocampal processing for the sequential tonal task are possible explanations.",

keywords = "Epilepsy, Evoked potentials, Hippocampus",

author = "Meador, {Kimford J.} and Loring, {David W.} and Gallagher, {Brian B.} and King, {Don W.} and Murro, {Anthony M} and Thompson, {Elaine E.} and Lee, {Gregory P} and Flanigin, {Herman F.} and Smith, {Joseph R.} and Jennifer Dushku and Harry Davis",

note = "Funding Information: We thank K. Stanford and J. Jackson for technical assistance and P. Turner for typing the manuscript. The research was supported in part by NIH/NIA grant #KO8 AG00314. The study was presented in part at the 1990 annual meeting of the American Academy of Neurology, Miami, FL.",

year = "1992",

doi = "10.3109/00207459208999792",

language = "English (US)",

volume = "66",

pages = "87--91",

journal = "International Journal of Neuroscience",

issn = "0020-7454",

publisher = "Informa Healthcare",

number = "1-2",

}

TY - JOUR

T1 - Differential effects of left versus right seizure focus on human hippocampal evoked responses

AU - Meador, Kimford J.

AU - Loring, David W.

AU - Gallagher, Brian B.

AU - King, Don W.

AU - Murro, Anthony M

AU - Thompson, Elaine E.

AU - Lee, Gregory P

AU - Flanigin, Herman F.

AU - Smith, Joseph R.

AU - Dushku, Jennifer

AU - Davis, Harry

N1 - Funding Information: We thank K. Stanford and J. Jackson for technical assistance and P. Turner for typing the manuscript. The research was supported in part by NIH/NIA grant #KO8 AG00314. The study was presented in part at the 1990 annual meeting of the American Academy of Neurology, Miami, FL.

PY - 1992

Y1 - 1992

N2 - Hippocampal evoked potentials were recorded using the P3 tonal oddball paradigm in 30 patients with unilateral temporal lobe seizure focus. Spectral power of the evoked potentials was decreased on the side of seizure focus, but this reduction was much greater when the focus was on the left. The effect of left/right focus does not appear to be due to group differences in age, sex, seizure duration, or operative pathology. Remote or finer left/right structural differences or differential left/right hippocampal processing for the sequential tonal task are possible explanations.

AB - Hippocampal evoked potentials were recorded using the P3 tonal oddball paradigm in 30 patients with unilateral temporal lobe seizure focus. Spectral power of the evoked potentials was decreased on the side of seizure focus, but this reduction was much greater when the focus was on the left. The effect of left/right focus does not appear to be due to group differences in age, sex, seizure duration, or operative pathology. Remote or finer left/right structural differences or differential left/right hippocampal processing for the sequential tonal task are possible explanations.

KW - Epilepsy

KW - Evoked potentials

KW - Hippocampus

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U2 - 10.3109/00207459208999792

DO - 10.3109/00207459208999792

M3 - Article

C2 - 1304573

AN - SCOPUS:0026920852

SN - 0020-7454

VL - 66

SP - 87

EP - 91

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

IS - 1-2

ER -

Differential effects of left versus right seizure focus on human hippocampal evoked responses

Abstract

Keywords

ASJC Scopus subject areas

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