Differentiation of breast tumors by ultrasonic tissue characterization

R. M. Golub, R. E. Parsons, B. Sigel, E. J. Feleppa, J. Justin, H. A. Zaren, M. Rorke, J. Sokil-Melgar, H. Kimitsuki

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


The ability of ultrasonic tissue characterization to differentiate and classify benign and malignant breast tissues in vivo in patients with palpable breast masses and in vitro in excised breast tissue was evaluated. One-hundred and twenty-four in vivo and 89 in vitro studies were performed using a technique of UTC based on parameters from the power spectrum of backscattered echoes. Sensitivities and specificities for diagnosing carcinoma were 86 and 84% for in vivo studies and 94 and 92% for in vitro studies. These UTC parameters provided threshold values for color-coding breast lesion images. The results of this preliminary investigation suggest that UTC provides a basis for assessing more accurately lesions suspected of being malignant prior to biopsy and possibly for evaluating breast lesions noninvasively.

Original languageEnglish (US)
Pages (from-to)601-608
Number of pages8
JournalJournal of Ultrasound in Medicine
Issue number10
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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