Differentiation of healthy brain tissue and tumors using Surface-enhanced Raman scattering

Ömer Aydin, Murat Altaş, Mehmet Kahraman, Ömer Faruk Bayrak, Mustafa Çulha

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Surface-enhanced Raman scattering (SERS) is a powerful technique for characterization of biological samples. SERS spectra from healthy brain tissue and tumors are obtained by sudden freezing of tissue in liquid nitrogen and crashing and mixing it with a concentrated silver colloidal suspension. The acquired spectra from tissues show significant spectral differences that can be used to identify whether it is from a healthy region or tumor. The most significant change on SERS spectra from the healthy/peripheral brain tissue to tumor is the increase of the ratio of the peaks at around 723 to 655 cm -1. In addition, the spectral changes indicate that the protein content in tumors increases compared to the peripheral/healthy tissue as observed with tumor invasion. The preliminary results show that SERS spectra can be used for a quick diagnosis due to the simplicity of the sample preparation and the speed of the spectral acquisition.

Original languageEnglish (US)
Pages (from-to)1095-1100
Number of pages6
JournalApplied Spectroscopy
Volume63
Issue number10
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Brain tumor
  • Diagnosis
  • SERS
  • Silver nanoparticles
  • Surface-enhanced Raman scattering
  • Tissue differentiation

ASJC Scopus subject areas

  • Instrumentation
  • Spectroscopy

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