Directing systemic oncolytic viral delivery to tumors via carrier cells

Hiroshi Nakashima, Balveen Kaur, E. A. Chiocca

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


The systemic administration of oncolytic virus (OV) is often inefficient due to clearance of the virus by host defense mechanism and spurious targeting of non-cancer tissues through the bloodstream. Cell mediated OV delivery could hide the virus from host defenses and direct them toward tumors: Mesencymal and neural stem cells have been described to possess tumor-homing ability as well as the capacity to deliver OVs. In this review, we will focus on approaches where OV and carrier cells are utilized for cancer therapy. Effective cellular internalization and replication of OVs need to occur both in cancer and carrier cells. We thus will discuss the current challenges faced by the use of OV delivery via carrier cells.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalCytokine and Growth Factor Reviews
Issue number2-3
StatePublished - Apr 2010
Externally publishedYes


  • Adenovirus
  • Carrier cells
  • HSV-1
  • MSC
  • NSC
  • Virus delivery

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)


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