Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers

Cecilia Arana Yi; Ghayathri Jeyakumar; Pedro Medina; Jorge Cortes; Sherry Pierce; Carlos Bueso-Ramos; Hagop Kantarjian; Srdan Verstovsek

doi:10.1016/j.leukres.2013.11.002

Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers

Cecilia Arana Yi, Ghayathri Jeyakumar, Pedro Medina, Jorge Cortes, Sherry Pierce, Carlos Bueso-Ramos, Hagop Kantarjian, Srdan Verstovsek

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Primary myelofibrosis (PMF) is myeloproliferative neoplasm whose diagnosis is based on a combination of clinical and pathology criteria. We evaluated 560 consecutive patients who were diagnosed with PMF upon a referral to our center and evaluated the frequency of and reasons for diagnostic discordance. Discordance in the diagnosis was found in 70 (12.5%) patients. Discordant cases had a significantly lower grade of bone marrow fibrosis (grade 0-1), more likely to be JAK2V617F-mutation negative, and have no peripheral blood blasts, possibly explaining the difficulty in making a proper diagnosis and underscoring the need for a complete evaluation at a tertiary center.

Original language	English (US)
Pages (from-to)	91-94
Number of pages	4
Journal	Leukemia Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2013.11.002
State	Published - Jan 2014
Externally published	Yes

Keywords

Diagnostic discrepancy
JAKV617F mutation
Primary myelofibrosis

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.leukres.2013.11.002

Cite this

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title = "Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers",

abstract = "Primary myelofibrosis (PMF) is myeloproliferative neoplasm whose diagnosis is based on a combination of clinical and pathology criteria. We evaluated 560 consecutive patients who were diagnosed with PMF upon a referral to our center and evaluated the frequency of and reasons for diagnostic discordance. Discordance in the diagnosis was found in 70 (12.5%) patients. Discordant cases had a significantly lower grade of bone marrow fibrosis (grade 0-1), more likely to be JAK2V617F-mutation negative, and have no peripheral blood blasts, possibly explaining the difficulty in making a proper diagnosis and underscoring the need for a complete evaluation at a tertiary center.",

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T1 - Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers

AU - Arana Yi, Cecilia

AU - Jeyakumar, Ghayathri

AU - Medina, Pedro

AU - Cortes, Jorge

AU - Pierce, Sherry

AU - Bueso-Ramos, Carlos

AU - Kantarjian, Hagop

AU - Verstovsek, Srdan

PY - 2014/1

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N2 - Primary myelofibrosis (PMF) is myeloproliferative neoplasm whose diagnosis is based on a combination of clinical and pathology criteria. We evaluated 560 consecutive patients who were diagnosed with PMF upon a referral to our center and evaluated the frequency of and reasons for diagnostic discordance. Discordance in the diagnosis was found in 70 (12.5%) patients. Discordant cases had a significantly lower grade of bone marrow fibrosis (grade 0-1), more likely to be JAK2V617F-mutation negative, and have no peripheral blood blasts, possibly explaining the difficulty in making a proper diagnosis and underscoring the need for a complete evaluation at a tertiary center.

AB - Primary myelofibrosis (PMF) is myeloproliferative neoplasm whose diagnosis is based on a combination of clinical and pathology criteria. We evaluated 560 consecutive patients who were diagnosed with PMF upon a referral to our center and evaluated the frequency of and reasons for diagnostic discordance. Discordance in the diagnosis was found in 70 (12.5%) patients. Discordant cases had a significantly lower grade of bone marrow fibrosis (grade 0-1), more likely to be JAK2V617F-mutation negative, and have no peripheral blood blasts, possibly explaining the difficulty in making a proper diagnosis and underscoring the need for a complete evaluation at a tertiary center.

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Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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