Discrimination of inflammatory bowel disease using Raman spectroscopy and linear discriminant analysis methods

Hao Ding, Ming Cao, Andrew W. Dupont, Larry D. Scott, Sushovan Guha, Shashideep Singhal, Mamoun Younes, Isaac Pence, Alan Joseph Herline, David Schwartz, Hua Xu, Anita Mahadevan-Jansen, Xiaohong Bi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Inflammatory bowel disease (IBD) is an idiopathic disease that is typically characterized by chronic inflammation of the gastrointestinal tract. Recently much effort has been devoted to the development of novel diagnostic tools that can assist physicians for fast, accurate, and automated diagnosis of the disease. Previous research based on Raman spectroscopy has shown promising results in differentiating IBD patients from normal screening cases. In the current study, we examined IBD patients in vivo through a colonoscope-coupled Raman system. Optical diagnosis for IBD discrimination was conducted based on full-range spectra using multivariate statistical methods. Further, we incorporated several feature selection methods in machine learning into the classification model. The diagnostic performance for disease differentiation was significantly improved after feature selection. Our results showed that improved IBD diagnosis can be achieved using Raman spectroscopy in combination with multivariate analysis and feature selection.

Original languageEnglish (US)
Title of host publicationBiomedical Vibrational Spectroscopy 2016
Subtitle of host publicationAdvances in Research and Industry
EditorsAnita Mahadevan-Jansen, Wolfgang Petrich
ISBN (Electronic)9781628419382
StatePublished - 2016
EventBiomedical Vibrational Spectroscopy 2016: Advances in Research and Industry - San Francisco, United States
Duration: Feb 13 2016Feb 14 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherBiomedical Vibrational Spectroscopy 2016: Advances in Research and Industry
Country/TerritoryUnited States
CitySan Francisco


  • Crohn's Colitis
  • Inflammatory Bowel Disease
  • Raman spectroscopy
  • Ulcerative Colitis
  • feature selection
  • multivariate analysis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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