TY - JOUR
T1 - Dissecting the genetic architecture of the cardiovascular and renal stress response
AU - Snieder, Harold
AU - Harshfield, Gregory A.
AU - Barbeau, Paule
AU - Pollock, David M.
AU - Pollock, Jennifer S.
AU - Treiber, Frank A.
N1 - Funding Information:
This study was supported by National Heart Lung and Blood Institute Grants HL56622 and 1 PO1 HL69999, HS also receives funding from the British Heart Foundation (FS/99050).
PY - 2002/10
Y1 - 2002/10
N2 - We review the evidence for a genetic basis of the cardiovascular and renal stress response. A bio-behavioral model of stress-induced hypertension is presented that explains how repeated exposure to stress in combination with genetic susceptibility might lead to the development of hypertension. In this model, we focus on three underlying physiological systems that mediate the stress response of the heart, vasculature and kidney: the sympathetic nervous system (SNS), the renin-angiotensin-aldosterone system (RAAS) and the endothelial system (ES). We then review the evidence for a genetic influence on cardiovascular reactivity to psychological stress and stress-induced sodium retention using data from twin and family studies and a limited number of candidate gene studies. Finally, by describing the underlying physiological systems of our model and their genetic underpinning we emphasize the importance of inclusion of genetic measurements in any future studies testing the reactivity hypothesis.
AB - We review the evidence for a genetic basis of the cardiovascular and renal stress response. A bio-behavioral model of stress-induced hypertension is presented that explains how repeated exposure to stress in combination with genetic susceptibility might lead to the development of hypertension. In this model, we focus on three underlying physiological systems that mediate the stress response of the heart, vasculature and kidney: the sympathetic nervous system (SNS), the renin-angiotensin-aldosterone system (RAAS) and the endothelial system (ES). We then review the evidence for a genetic influence on cardiovascular reactivity to psychological stress and stress-induced sodium retention using data from twin and family studies and a limited number of candidate gene studies. Finally, by describing the underlying physiological systems of our model and their genetic underpinning we emphasize the importance of inclusion of genetic measurements in any future studies testing the reactivity hypothesis.
KW - Cardiovascular reactivity
KW - Genetics
KW - Hypertension
KW - Stress
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U2 - 10.1016/S0301-0511(02)00053-4
DO - 10.1016/S0301-0511(02)00053-4
M3 - Article
C2 - 12385670
AN - SCOPUS:0036774447
SN - 0301-0511
VL - 61
SP - 73
EP - 95
JO - Biological Psychology
JF - Biological Psychology
IS - 1-2
ER -