Abstract
We established a novel model of myocarditis induced with Theiler's murine encephalomyelitis virus (TMEV), which has been used as a viral model for multiple sclerosis and seizure/epilepsy. Following TMEV infection, C3H mice developed severe myocarditis with T cell infiltration, while C57BL/6 mice had mild lesions and SJL/J mice had no inflammation in the heart. In C3H mice, myocarditis was divided into three phases: acute viral, subacute immune, and chronic fibrotic phases. Using toll-like receptor (TLR) 4-deficient C3H mice, we found that interleukin (IL)-6, IL-17, TLR4, and anti-viral immune responses were associated with myocarditis susceptibility.
Original language | English (US) |
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Pages (from-to) | 85-93 |
Number of pages | 9 |
Journal | Cellular Immunology |
Volume | 292 |
Issue number | 1-2 |
DOIs | |
State | Published - Nov 1 2014 |
Externally published | Yes |
Keywords
- Autoimmunity
- CNS demyelinating disease
- Echocardiography
- Fibrosis
- IL-6
- Infectious disease
- Picornaviridae infection
- Toll-like receptor
- Tropism
- Troponin
ASJC Scopus subject areas
- Immunology