Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei

Miyuki Tauchi; Rong Zhang; David A. D'Alessio; Javier Eduardo Stern; James P. Herman

doi:10.1016/j.jchemneu.2008.07.009

Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei

Miyuki Tauchi, Rong Zhang, David A. D'Alessio, Javier Eduardo Stern, James P. Herman

Graduate Studies

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1 fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling. The current study was designed to establish domains of GLP-1 action, focusing on axosomatic appositions on different neuroendocrine and autonomic cell populations in the PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on corticotropin-releasing hormone neurons in the medial parvocellular PVN. GLP-1 positive boutons can also be observed in apposition to oxytocinergic neurons and on retrogradely labeled pre-autonomic neurons projecting to the region of the nucleus of the solitary tract. In contrast, there were very few vasopressinergic neurons with GLP-1 appositions. Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLP-1 on adrenocorticotropin release. GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays.

Original language	English (US)
Pages (from-to)	144-149
Number of pages	6
Journal	Journal of Chemical Neuroanatomy
Volume	36
Issue number	3-4
DOIs	https://doi.org/10.1016/j.jchemneu.2008.07.009
State	Published - Dec 2008

Keywords

Arginine vasopressin
Corticotrophin releasing hormone
Fluorogold
Nucleus of the solitary tract
Oxytocin
Pre-autonomic
Retrograde tracing

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.1016/j.jchemneu.2008.07.009

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@article{96911fa53c9841478d064d8eb6581788,

title = "Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei",

abstract = "Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1 fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling. The current study was designed to establish domains of GLP-1 action, focusing on axosomatic appositions on different neuroendocrine and autonomic cell populations in the PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on corticotropin-releasing hormone neurons in the medial parvocellular PVN. GLP-1 positive boutons can also be observed in apposition to oxytocinergic neurons and on retrogradely labeled pre-autonomic neurons projecting to the region of the nucleus of the solitary tract. In contrast, there were very few vasopressinergic neurons with GLP-1 appositions. Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLP-1 on adrenocorticotropin release. GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays.",

keywords = "Arginine vasopressin, Corticotrophin releasing hormone, Fluorogold, Nucleus of the solitary tract, Oxytocin, Pre-autonomic, Retrograde tracing",

author = "Miyuki Tauchi and Rong Zhang and D'Alessio, {David A.} and Stern, {Javier Eduardo} and Herman, {James P.}",

note = "Funding Information: Funded by National Institute of Mental Health; Grant Number MH069680.",

year = "2008",

month = dec,

doi = "10.1016/j.jchemneu.2008.07.009",

language = "English (US)",

volume = "36",

pages = "144--149",

journal = "Journal of Chemical Neuroanatomy",

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publisher = "Elsevier B.V.",

number = "3-4",

}

TY - JOUR

T1 - Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei

AU - Tauchi, Miyuki

AU - Zhang, Rong

AU - D'Alessio, David A.

AU - Stern, Javier Eduardo

AU - Herman, James P.

N1 - Funding Information: Funded by National Institute of Mental Health; Grant Number MH069680.

PY - 2008/12

Y1 - 2008/12

N2 - Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1 fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling. The current study was designed to establish domains of GLP-1 action, focusing on axosomatic appositions on different neuroendocrine and autonomic cell populations in the PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on corticotropin-releasing hormone neurons in the medial parvocellular PVN. GLP-1 positive boutons can also be observed in apposition to oxytocinergic neurons and on retrogradely labeled pre-autonomic neurons projecting to the region of the nucleus of the solitary tract. In contrast, there were very few vasopressinergic neurons with GLP-1 appositions. Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLP-1 on adrenocorticotropin release. GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays.

AB - Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1 fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling. The current study was designed to establish domains of GLP-1 action, focusing on axosomatic appositions on different neuroendocrine and autonomic cell populations in the PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on corticotropin-releasing hormone neurons in the medial parvocellular PVN. GLP-1 positive boutons can also be observed in apposition to oxytocinergic neurons and on retrogradely labeled pre-autonomic neurons projecting to the region of the nucleus of the solitary tract. In contrast, there were very few vasopressinergic neurons with GLP-1 appositions. Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLP-1 on adrenocorticotropin release. GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays.

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KW - Corticotrophin releasing hormone

KW - Fluorogold

KW - Nucleus of the solitary tract

KW - Oxytocin

KW - Pre-autonomic

KW - Retrograde tracing

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ER -

Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei

Abstract

Keywords

ASJC Scopus subject areas

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