Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: Relationship to other populations

Bo Feng Zhu, Guang Yang, Chun Mei Shen, Hai Xia Qin, Shun Zhi Liu, Ya Jun Deng, Shuan Liang Fan, Li Bin Deng, Feng Chen, Ping Zhang, Jie Fang, Li Ping Chen, Hong Dan Wang, Zhen Yuan Wang, Rudolf Lucas

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A2402 (32.46%), A1101 (26.32%), and A0203 (10.09%) at the HLA-A locus and B4601 (12.28%), B1525 (10.09%), B4001 (8.77%), and B3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A2402-B1525 (7.86%) and A0203-B3802 (5.64%), followed by A1101-B4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.

Original languageEnglish (US)
Pages (from-to)127-135
Number of pages9
JournalJournal of Zhejiang University: Science B
Issue number2
StatePublished - Feb 2010


  • Allele
  • HLA-B
  • Haplotype
  • Human leukocyte antigen (HLA)-A
  • Polymerase chain reaction-sequence-based typing (PCR-SBT)
  • Yi ethnic minority

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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