Domperidone, an inhibitor of the D2-receptor, blocks a late phase of an electrically induced long-term potentiation in the CA1-region in rats

U. Frey; S. Hartmann; H. Matthies

Domperidone, an inhibitor of the D2-receptor, blocks a late phase of an electrically induced long-term potentiation in the CA1-region in rats

U. Frey
, S. Hartmann
, H. Matthies

Neurology

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

The influence of the D2-receptorblocker domperidone (DP) at a concentration of 1 μM was investigated on an electrically induced long-term potentiation (LTP) measured as the enhancement of the population spike (PS) amplitude in the hippocampal CA1. It could be shown that the drug does not influence the initiation but the maintenance of LTP. The results once again support the hypothesis that different phases of LTP exist which are realized by different cellular inputs.

Original language	English (US)
Pages (from-to)	473-476
Number of pages	4
Journal	Biomedica Biochimica Acta
Volume	48
Issue number	7
State	Published - Jan 1 1989

ASJC Scopus subject areas

Biochemistry

Cite this

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abstract = "The influence of the D2-receptorblocker domperidone (DP) at a concentration of 1 μM was investigated on an electrically induced long-term potentiation (LTP) measured as the enhancement of the population spike (PS) amplitude in the hippocampal CA1. It could be shown that the drug does not influence the initiation but the maintenance of LTP. The results once again support the hypothesis that different phases of LTP exist which are realized by different cellular inputs.",

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AU - Hartmann, S.

AU - Matthies, H.

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N2 - The influence of the D2-receptorblocker domperidone (DP) at a concentration of 1 μM was investigated on an electrically induced long-term potentiation (LTP) measured as the enhancement of the population spike (PS) amplitude in the hippocampal CA1. It could be shown that the drug does not influence the initiation but the maintenance of LTP. The results once again support the hypothesis that different phases of LTP exist which are realized by different cellular inputs.

AB - The influence of the D2-receptorblocker domperidone (DP) at a concentration of 1 μM was investigated on an electrically induced long-term potentiation (LTP) measured as the enhancement of the population spike (PS) amplitude in the hippocampal CA1. It could be shown that the drug does not influence the initiation but the maintenance of LTP. The results once again support the hypothesis that different phases of LTP exist which are realized by different cellular inputs.

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M3 - Article

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AN - SCOPUS:0024401101

SN - 0232-766X

VL - 48

SP - 473

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JO - Biomedica Biochimica Acta

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IS - 7

ER -

Domperidone, an inhibitor of the D2-receptor, blocks a late phase of an electrically induced long-term potentiation in the CA1-region in rats

Abstract

ASJC Scopus subject areas

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