Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Pooyan Makvandi, Uros Josic, Masoud Delfi, Filippo Pinelli, Vahid Jahed, Emine Kaya, Milad Ashrafizadeh, Atefeh Zarepour, Filippo Rossi, Ali Zarrabi, Tarun Agarwal, Ehsan Nazarzadeh Zare, Matineh Ghomi, Tapas Kumar Maiti, Lorenzo Breschi, Franklin R. Tay

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations


The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

Original languageEnglish (US)
Article number2004014
JournalAdvanced Science
Issue number8
StatePublished - Apr 21 2021


  • antibacterial
  • antiviral
  • drug delivery
  • oral cancer
  • tissue regeneration

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Engineering(all)
  • Physics and Astronomy(all)


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