TY - JOUR
T1 - Drugs of abuse and placental transport
AU - Ganapathy, Vadivel
AU - Prasad, Puttur D.
AU - Ganapathy, Malliga E.
AU - Leibach, Frederick H.
N1 - Funding Information:
This work was supported by the National Institutes of Health Grants DA 10045 (VG) and GM 54122 (MEG). The authors thank Ida O. Walker for excellent secretarial assistance.
PY - 1999/6/14
Y1 - 1999/6/14
N2 - The placenta provides the only link between the mother and the developing fetus. The function of the placenta as a transport organ is obligatory for fetal development because this process, mediated by a variety of transport systems, is responsible for the delivery of nutrients from the mother to the fetus. Some of the transport systems in the placenta also play a role in the clearance of vasoactive compounds, thus maintaining optimal blood flow to this organ. There is strong supporting evidence to indicate that several of these placental transport systems are either direct or indirect targets for the abusable drugs cocaine, amphetamines, nicotine, and cannabinoids. These drugs of abuse compromise the placental transport function and consequently produce detrimental effects on the developing fetus. Copyright (C) 1999 Elsevier Science B.V.
AB - The placenta provides the only link between the mother and the developing fetus. The function of the placenta as a transport organ is obligatory for fetal development because this process, mediated by a variety of transport systems, is responsible for the delivery of nutrients from the mother to the fetus. Some of the transport systems in the placenta also play a role in the clearance of vasoactive compounds, thus maintaining optimal blood flow to this organ. There is strong supporting evidence to indicate that several of these placental transport systems are either direct or indirect targets for the abusable drugs cocaine, amphetamines, nicotine, and cannabinoids. These drugs of abuse compromise the placental transport function and consequently produce detrimental effects on the developing fetus. Copyright (C) 1999 Elsevier Science B.V.
KW - Amino acid transport
KW - Amphetamines
KW - Cannabinoids
KW - Cocaine
KW - Extraneuronal monoamine transporter
KW - Norepinephrine transporter
KW - Serotonin transporter
KW - Sigma receptor
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U2 - 10.1016/S0169-409X(99)00009-5
DO - 10.1016/S0169-409X(99)00009-5
M3 - Article
AN - SCOPUS:0032962822
SN - 0169-409X
VL - 38
SP - 99
EP - 110
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 1
ER -