TY - JOUR
T1 - Dysregulated cellular metabolism in atherosclerosis
T2 - mediators and therapeutic opportunities
AU - Stroope, Chad
AU - Nettersheim, Felix Sebastian
AU - Coon, Brian
AU - Finney, Alexandra C.
AU - Schwartz, Martin A.
AU - Ley, Klaus
AU - Rom, Oren
AU - Yurdagul, Arif
N1 - Publisher Copyright:
© Springer Nature Limited 2024.
PY - 2024/4
Y1 - 2024/4
N2 - Accumulating evidence over the past decades has revealed an intricate relationship between dysregulation of cellular metabolism and the progression of atherosclerotic cardiovascular disease. However, an integrated understanding of dysregulated cellular metabolism in atherosclerotic cardiovascular disease and its potential value as a therapeutic target is missing. In this Review, we (1) summarize recent advances concerning the role of metabolic dysregulation during atherosclerosis progression in lesional cells, including endothelial cells, vascular smooth muscle cells, macrophages and T cells; (2) explore the complexity of metabolic cross-talk between these lesional cells; (3) highlight emerging technologies that promise to illuminate unknown aspects of metabolism in atherosclerosis; and (4) suggest strategies for targeting these underexplored metabolic alterations to mitigate atherosclerosis progression and stabilize rupture-prone atheromas with a potential new generation of cardiovascular therapeutics.
AB - Accumulating evidence over the past decades has revealed an intricate relationship between dysregulation of cellular metabolism and the progression of atherosclerotic cardiovascular disease. However, an integrated understanding of dysregulated cellular metabolism in atherosclerotic cardiovascular disease and its potential value as a therapeutic target is missing. In this Review, we (1) summarize recent advances concerning the role of metabolic dysregulation during atherosclerosis progression in lesional cells, including endothelial cells, vascular smooth muscle cells, macrophages and T cells; (2) explore the complexity of metabolic cross-talk between these lesional cells; (3) highlight emerging technologies that promise to illuminate unknown aspects of metabolism in atherosclerosis; and (4) suggest strategies for targeting these underexplored metabolic alterations to mitigate atherosclerosis progression and stabilize rupture-prone atheromas with a potential new generation of cardiovascular therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85188703221&partnerID=8YFLogxK
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U2 - 10.1038/s42255-024-01015-w
DO - 10.1038/s42255-024-01015-w
M3 - Review article
C2 - 38532071
AN - SCOPUS:85188703221
SN - 2522-5812
VL - 6
SP - 617
EP - 638
JO - Nature Metabolism
JF - Nature Metabolism
IS - 4
ER -
