Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes

Kaisa M. Kemppainen; Alexandria N. Ardissone; Austin G. Davis-Richardson; Jennie R. Fagen; Kelsey A. Gano; Luis G. León-Novelo; Kendra Vehik; George Casella; Olli Simell; Anette G. Ziegler; Marian J. Rewers; Åke Lernmark; William Hagopian; Jin Xiong She; Jeffrey P. Krischer; Beena Akolkar; Desmond A. Schatz; Mark A. Atkinson; Eric W. Triplett

doi:10.2337/dc14-0850

Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes

Kaisa M. Kemppainen, Alexandria N. Ardissone, Austin G. Davis-Richardson, Jennie R. Fagen, Kelsey A. Gano, Luis G. León-Novelo, Kendra Vehik, George Casella, Olli Simell, Anette G. Ziegler, Marian J. Rewers, Åke Lernmark, William Hagopian, Jin Xiong She, Jeffrey P. Krischer, Beena Akolkar, Desmond A. Schatz, Mark A. Atkinson, Eric W. Triplett

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

OBJECTIVE: Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines howgeographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS: High-throughput 16S rRNA sequencing was performed on stool samples collected from 90 high-risk, nonautoimmune infants participating in The Environmental Determinants of Diabetes in the Young (TEDDY) study in the U.S., Germany, Sweden, and Finland. RESULTS: Study site-specific patterns of gut colonization share characteristics across continents. Finland and Colorado have a significantly lower bacterial diversity, while Sweden and Washington state are dominated by Bifidobacterium in early life. Bacterial community diversity over time is significantly different by geographical location. CONCLUSIONS: The microbiome of high-risk infants is associated with geographical location. Future studies aiming to identify the microbiome disease phenotype need to carefully consider the geographical origin of subjects.

Original language	English (US)
Pages (from-to)	329-332
Number of pages	4
Journal	Diabetes Care
Volume	38
Issue number	2
DOIs	https://doi.org/10.2337/dc14-0850
State	Published - Feb 1 2015
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialized Nursing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/dc14-0850

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Kemppainen, K. M., Ardissone, A. N., Davis-Richardson, A. G., Fagen, J. R., Gano, K. A., León-Novelo, L. G., Vehik, K., Casella, G., Simell, O., Ziegler, A. G., Rewers, M. J., Lernmark, Å., Hagopian, W., She, J. X., Krischer, J. P., Akolkar, B., Schatz, D. A., Atkinson, M. A., & Triplett, E. W. (2015). Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Diabetes Care, 38(2), 329-332. https://doi.org/10.2337/dc14-0850

Kemppainen, KM, Ardissone, AN, Davis-Richardson, AG, Fagen, JR, Gano, KA, León-Novelo, LG, Vehik, K, Casella, G, Simell, O, Ziegler, AG, Rewers, MJ, Lernmark, Å, Hagopian, W, She, JX, Krischer, JP, Akolkar, B, Schatz, DA, Atkinson, MA & Triplett, EW 2015, 'Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes', Diabetes Care, vol. 38, no. 2, pp. 329-332. https://doi.org/10.2337/dc14-0850

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title = "Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes",

abstract = "OBJECTIVE: Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines howgeographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS: High-throughput 16S rRNA sequencing was performed on stool samples collected from 90 high-risk, nonautoimmune infants participating in The Environmental Determinants of Diabetes in the Young (TEDDY) study in the U.S., Germany, Sweden, and Finland. RESULTS: Study site-specific patterns of gut colonization share characteristics across continents. Finland and Colorado have a significantly lower bacterial diversity, while Sweden and Washington state are dominated by Bifidobacterium in early life. Bacterial community diversity over time is significantly different by geographical location. CONCLUSIONS: The microbiome of high-risk infants is associated with geographical location. Future studies aiming to identify the microbiome disease phenotype need to carefully consider the geographical origin of subjects.",

author = "Kemppainen, {Kaisa M.} and Ardissone, {Alexandria N.} and Davis-Richardson, {Austin G.} and Fagen, {Jennie R.} and Gano, {Kelsey A.} and Le{\'o}n-Novelo, {Luis G.} and Kendra Vehik and George Casella and Olli Simell and Ziegler, {Anette G.} and Rewers, {Marian J.} and {\AA}ke Lernmark and William Hagopian and She, {Jin Xiong} and Krischer, {Jeffrey P.} and Beena Akolkar and Schatz, {Desmond A.} and Atkinson, {Mark A.} and Triplett, {Eric W.}",

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doi = "10.2337/dc14-0850",

language = "English (US)",

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AU - Kemppainen, Kaisa M.

AU - Ardissone, Alexandria N.

AU - Davis-Richardson, Austin G.

AU - Fagen, Jennie R.

AU - Gano, Kelsey A.

AU - León-Novelo, Luis G.

AU - Vehik, Kendra

AU - Casella, George

AU - Simell, Olli

AU - Ziegler, Anette G.

AU - Rewers, Marian J.

AU - Lernmark, Åke

AU - Hagopian, William

AU - She, Jin Xiong

AU - Krischer, Jeffrey P.

AU - Akolkar, Beena

AU - Schatz, Desmond A.

AU - Atkinson, Mark A.

AU - Triplett, Eric W.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - OBJECTIVE: Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines howgeographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS: High-throughput 16S rRNA sequencing was performed on stool samples collected from 90 high-risk, nonautoimmune infants participating in The Environmental Determinants of Diabetes in the Young (TEDDY) study in the U.S., Germany, Sweden, and Finland. RESULTS: Study site-specific patterns of gut colonization share characteristics across continents. Finland and Colorado have a significantly lower bacterial diversity, while Sweden and Washington state are dominated by Bifidobacterium in early life. Bacterial community diversity over time is significantly different by geographical location. CONCLUSIONS: The microbiome of high-risk infants is associated with geographical location. Future studies aiming to identify the microbiome disease phenotype need to carefully consider the geographical origin of subjects.

AB - OBJECTIVE: Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines howgeographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS: High-throughput 16S rRNA sequencing was performed on stool samples collected from 90 high-risk, nonautoimmune infants participating in The Environmental Determinants of Diabetes in the Young (TEDDY) study in the U.S., Germany, Sweden, and Finland. RESULTS: Study site-specific patterns of gut colonization share characteristics across continents. Finland and Colorado have a significantly lower bacterial diversity, while Sweden and Washington state are dominated by Bifidobacterium in early life. Bacterial community diversity over time is significantly different by geographical location. CONCLUSIONS: The microbiome of high-risk infants is associated with geographical location. Future studies aiming to identify the microbiome disease phenotype need to carefully consider the geographical origin of subjects.

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Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes

Abstract

ASJC Scopus subject areas

UN SDGs

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