Effect of age on gingival crevicular fluid concentrations of MIF and PGE2

C. Nonnenmacher, K. Helms, M. Bacher, R. M. Nüsing, C. Susin, R. Mutters, L. Flores-de-Jacoby, R. Mengel

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


We used an experimental gingivitis study design to compare crevicular fluid concentrations of Migration Inhibitory Factor (MIF) and Prostaglandin E 2(PGE2) in younger (18 to 30 yrs) and older (46 to 77 yrs) healthy adults. PGE2 increased after 1 wk in younger participants, whereas it decreased in older individuals after 1 wk of plaque accumulation. A significant interaction between age and time was observed for PGE2 (p = 0.04). High concentrations of MIF were identified in both age groups at baseline. MIF increased in the younger participants, whereas in the older individuals a decrease over time was observed. MIF concentration was positively correlated with plaque index and gingival index in the older age group. Total counts of bacteria, Parvimonas micra and Prevotella intermedia, were significantly correlated with MIF concentration in older participants. In conclusion, MIF and PGE2 production in response to bacterial accumulation seems to be modified by age.

Original languageEnglish (US)
Pages (from-to)639-643
Number of pages5
JournalJournal of Dental Research
Issue number7
StatePublished - Jul 1 2009
Externally publishedYes


  • Age
  • Experimental gingivitis
  • MIF
  • PGE
  • Real-time PCR

ASJC Scopus subject areas

  • General Dentistry


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