Effect of Anteroventral Third Ventricle Lesions on Vascular Sodium-Pump Activity in Two-Kidney Goldblatt Hypertension

Emel Songu-Mize; Steve L. Bealer; Robert William Caldwell

doi:10.1161/01.hyp.5.2_pt_2.i89

Effect of Anteroventral Third Ventricle Lesions on Vascular Sodium-Pump Activity in Two-Kidney Goldblatt Hypertension

Emel Songu-Mize, Steve L. Bealer, Robert William Caldwell

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We studied the effects of anteroventral third ventricle (AV3V) lesions on the vascular Na⁺-pump activity and blood pressure of rats prepared by the two-kidney Goldblatt procedure. Blood pressures and Na⁺-pump activity of the isolated tail arteries, measured as ouabain-sensitive⁸⁶Rb⁺- uptake, were determined in rats with renal artery clips, rats with AV3V lesions, and rats with AV3V lesions. Rats with renal artery clips developed higher blood pressures (40%) and higher vascular Na⁺- pump activity (20%-35%) than rats with no renal clips. Placement of AV3V lesions prior to the placement of renal clips prevented the increase in blood pressure and the increase in vascular Na⁺- pump activity. Plasma potassium and creatinine concentrations, nonspecific⁸⁶Rb⁺-uptake, and hematocrit were not different among these groups. Plasma sodium concentration was elevated in the AV3V lesioned control group. These experiments suggest a possible role of this CNS region in the regulation of vascular Na⁺-pump function during hypertensive states.

Original language	English (US)
Pages (from-to)	I-89-I-93
Journal	Hypertension
Volume	5
Issue number	2
DOIs	https://doi.org/10.1161/01.hyp.5.2_pt_2.i89
State	Published - 1983
Externally published	Yes

Keywords

AV3V lesion
Na-pump activity
One clip Goldblatt hypertension
Rb-uptake
Renal artery clips
Tail artery
Two-kidney

ASJC Scopus subject areas

Internal Medicine

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10.1161/01.hyp.5.2_pt_2.i89

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title = "Effect of Anteroventral Third Ventricle Lesions on Vascular Sodium-Pump Activity in Two-Kidney Goldblatt Hypertension",

abstract = "We studied the effects of anteroventral third ventricle (AV3V) lesions on the vascular Na+-pump activity and blood pressure of rats prepared by the two-kidney Goldblatt procedure. Blood pressures and Na+-pump activity of the isolated tail arteries, measured as ouabain-sensitive86Rb+- uptake, were determined in rats with renal artery clips, rats with AV3V lesions, and rats with AV3V lesions. Rats with renal artery clips developed higher blood pressures (40%) and higher vascular Na+- pump activity (20%-35%) than rats with no renal clips. Placement of AV3V lesions prior to the placement of renal clips prevented the increase in blood pressure and the increase in vascular Na+- pump activity. Plasma potassium and creatinine concentrations, nonspecific86Rb+-uptake, and hematocrit were not different among these groups. Plasma sodium concentration was elevated in the AV3V lesioned control group. These experiments suggest a possible role of this CNS region in the regulation of vascular Na+-pump function during hypertensive states.",

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author = "Emel Songu-Mize and Bealer, {Steve L.} and Caldwell, {Robert William}",

year = "1983",

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AU - Caldwell, Robert William

PY - 1983

Y1 - 1983

N2 - We studied the effects of anteroventral third ventricle (AV3V) lesions on the vascular Na+-pump activity and blood pressure of rats prepared by the two-kidney Goldblatt procedure. Blood pressures and Na+-pump activity of the isolated tail arteries, measured as ouabain-sensitive86Rb+- uptake, were determined in rats with renal artery clips, rats with AV3V lesions, and rats with AV3V lesions. Rats with renal artery clips developed higher blood pressures (40%) and higher vascular Na+- pump activity (20%-35%) than rats with no renal clips. Placement of AV3V lesions prior to the placement of renal clips prevented the increase in blood pressure and the increase in vascular Na+- pump activity. Plasma potassium and creatinine concentrations, nonspecific86Rb+-uptake, and hematocrit were not different among these groups. Plasma sodium concentration was elevated in the AV3V lesioned control group. These experiments suggest a possible role of this CNS region in the regulation of vascular Na+-pump function during hypertensive states.

AB - We studied the effects of anteroventral third ventricle (AV3V) lesions on the vascular Na+-pump activity and blood pressure of rats prepared by the two-kidney Goldblatt procedure. Blood pressures and Na+-pump activity of the isolated tail arteries, measured as ouabain-sensitive86Rb+- uptake, were determined in rats with renal artery clips, rats with AV3V lesions, and rats with AV3V lesions. Rats with renal artery clips developed higher blood pressures (40%) and higher vascular Na+- pump activity (20%-35%) than rats with no renal clips. Placement of AV3V lesions prior to the placement of renal clips prevented the increase in blood pressure and the increase in vascular Na+- pump activity. Plasma potassium and creatinine concentrations, nonspecific86Rb+-uptake, and hematocrit were not different among these groups. Plasma sodium concentration was elevated in the AV3V lesioned control group. These experiments suggest a possible role of this CNS region in the regulation of vascular Na+-pump function during hypertensive states.

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Effect of Anteroventral Third Ventricle Lesions on Vascular Sodium-Pump Activity in Two-Kidney Goldblatt Hypertension

Abstract

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