Effect of charge on the distribution and retention of macromolecules in the artery wall

Ann L. Baldwin; Lisa M. Wilson; Brooke J. McGuire

Effect of charge on the distribution and retention of macromolecules in the artery wall

Ann L. Baldwin, Lisa M. Wilson, Brooke J. McGuire

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Experiments were performed on rabbit aorta and femoral arteries to test the hypothesis that neutral dextran, of a similar molecular weight to albumin, does not show preferential lamellar binding and is rapidly removed from the arterial wall by immersion in tracer-free solution. Results demonstrate that the distribution of macromolecules within the aortic wall is not just size dependent, but also depend on the degree of interaction between the macromolecule and arterial wall components, such as elastin.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publisher	ASME
Pages	475-476
Number of pages	2
Volume	42
ISBN (Print)	0791816117
State	Published - Dec 1 1999
Externally published	Yes
Event	1999 Bioengineering Conference - Big Sky, MT, USA Duration: Jun 16 1999 → Jun 20 1999

Other

Other	1999 Bioengineering Conference
City	Big Sky, MT, USA
Period	6/16/99 → 6/20/99

ASJC Scopus subject areas

General Engineering

Cite this

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title = "Effect of charge on the distribution and retention of macromolecules in the artery wall",

abstract = "Experiments were performed on rabbit aorta and femoral arteries to test the hypothesis that neutral dextran, of a similar molecular weight to albumin, does not show preferential lamellar binding and is rapidly removed from the arterial wall by immersion in tracer-free solution. Results demonstrate that the distribution of macromolecules within the aortic wall is not just size dependent, but also depend on the degree of interaction between the macromolecule and arterial wall components, such as elastin.",

author = "Baldwin, {Ann L.} and Wilson, {Lisa M.} and McGuire, {Brooke J.}",

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AU - Baldwin, Ann L.

AU - Wilson, Lisa M.

AU - McGuire, Brooke J.

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Y1 - 1999/12/1

N2 - Experiments were performed on rabbit aorta and femoral arteries to test the hypothesis that neutral dextran, of a similar molecular weight to albumin, does not show preferential lamellar binding and is rapidly removed from the arterial wall by immersion in tracer-free solution. Results demonstrate that the distribution of macromolecules within the aortic wall is not just size dependent, but also depend on the degree of interaction between the macromolecule and arterial wall components, such as elastin.

AB - Experiments were performed on rabbit aorta and femoral arteries to test the hypothesis that neutral dextran, of a similar molecular weight to albumin, does not show preferential lamellar binding and is rapidly removed from the arterial wall by immersion in tracer-free solution. Results demonstrate that the distribution of macromolecules within the aortic wall is not just size dependent, but also depend on the degree of interaction between the macromolecule and arterial wall components, such as elastin.

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M3 - Conference contribution

AN - SCOPUS:0033298596

SN - 0791816117

VL - 42

SP - 475

EP - 476

BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

PB - ASME

T2 - 1999 Bioengineering Conference

Y2 - 16 June 1999 through 20 June 1999

ER -

Effect of charge on the distribution and retention of macromolecules in the artery wall

Abstract

Other

ASJC Scopus subject areas

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