TY - JOUR
T1 - Effect of Chronic Hypoxia on Angiotensin-lnduced Pulmonary Vasoconstriction and Converting Enzyme Activity in the Rat1
AU - Caldwell, Robert W.
AU - Blatteis, Clark M.
N1 - Funding Information:
Supported by a grant from American Heart Association, Tennessee Affiliate.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1983/3
Y1 - 1983/3
N2 - Rats were exposed to high-altitude (5500 m) hypoxia for 2 weeks. On examination 1-3 days after return to sea level and compared with control rats, they exhibited pulmonary hypertension, reduced angiotensin-converting enzyme activity, greater vascular responsiveness to angiotensin II (AII), and resistance to blockade of AII pulmonary pressor responses by the AII antagonist, saralasin.
AB - Rats were exposed to high-altitude (5500 m) hypoxia for 2 weeks. On examination 1-3 days after return to sea level and compared with control rats, they exhibited pulmonary hypertension, reduced angiotensin-converting enzyme activity, greater vascular responsiveness to angiotensin II (AII), and resistance to blockade of AII pulmonary pressor responses by the AII antagonist, saralasin.
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U2 - 10.3181/00379727-172-41568
DO - 10.3181/00379727-172-41568
M3 - Article
C2 - 6302709
AN - SCOPUS:0020664110
SN - 1535-3702
VL - 172
SP - 346
EP - 350
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
IS - 3
ER -