Effect of chronic renal medullary nitric oxide inhibition on blood pressure

D. L. Mattson, S. Lu, K. Nakanishi, P. E. Papanek, A. W. Cowley

Research output: Contribution to journalArticlepeer-review

194 Scopus citations


The effects of chronic nitric oxide inhibition in the renal medulla on renal cortical and medullary blood flow, sodium balance, and blood pressure were evaluated in conscious uninephrectomized Sprague-Dawley rats. During a 5-day renal medullary interstitial infusion of the nitric oxide inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 120 μg/h) in saline (0.5 ml/min), renal medullary blood flow was selectively decreased by 30% after 2 h and was maintained at that level for the entire infusion. The decrease in medullary blood flow was associated with sodium retention and increased blood pressure. After the cessation of L-NAME infusion, medullary blood flow returned to control, and the sodium balance became negative as blood pressure returned to baseline. These data indicate that renal medullary nitric oxide plays an important role in the regulation of renal blood flow, sodium excretion, and blood pressure.

Original languageEnglish (US)
Pages (from-to)H1918-H1926
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number5 35-5
StatePublished - Jan 1 1994
Externally publishedYes


  • hypertension
  • laser-Doppler flowmetry
  • renal hemodynamics
  • renal medulla

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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