Abstract
To explore the role of the depolarization in high K+ induced enhancement of phosphoinositide turnover in frog skeletal muscle, the effect of Ca2+ free high K+ solution saturated with dantrolene sodium (DaNa) was investigated. It was found that, in comparison with the effect of normal high K+ solution (Dong et al. 1992), the turnover of phosphoinositides was similarly enhanced, and the contracture significantly reduced, though not completely prevented. It was indicated that the depolarization was still accompanied by a rise of myoplasmic free calcium. In view of the calcium dependence of phospholipase C activity, the present study supports the notion that elevation of [Ca2+](i) is not the only factor and depolarization probably plays some roles in the high K+ induced enhancement of phosphoinositide turnover.
Original language | English (US) |
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Pages (from-to) | 64-70 |
Number of pages | 7 |
Journal | Chinese Journal of Physiological Sciences |
Volume | 13 |
Issue number | 1 |
State | Published - Jan 1 1997 |
Externally published | Yes |
Keywords
- Dantrolene sodium
- High potassium
- Phosphoinositide
- Skeletal muscle
ASJC Scopus subject areas
- Physiology