Effect of interleukin-2 and mitogen on in vitro immunoglobulin production by peripheral blood lymphocytes from patients with selective IgM deficiency

J. E. Moffitt; Margaret Frank Guill; Betty Beasley Wray; D. A. Brown; N. W. Peacocke; E. W. Ades

Effect of interleukin-2 and mitogen on in vitro immunoglobulin production by peripheral blood lymphocytes from patients with selective IgM deficiency

J. E. Moffitt
, Margaret Frank Guill
, Betty Beasley Wray
, D. A. Brown
, N. W. Peacocke
, E. W. Ades

Research output: Contribution to journal › Article › peer-review

Abstract

Immunoglobulin production by mitogen and recombinant interleukin-2-(rIL-2)-stimulated lymphocytes from IgM-deficient patients was studied. The findings were that subnormal serum IgM levels did not necessarily predict defective in vitro IgG or IgM production, lymphocytes from some IgM-deficient patients exhibited defective T cell function, and rIL-2 did not enhance defective in vitro immunoglobulin production.

Original language	English (US)
Pages (from-to)	424-427
Number of pages	4
Journal	Annals of Allergy
Volume	61
Issue number	6
State	Published - Dec 1 1988

ASJC Scopus subject areas

Immunology and Allergy

Cite this

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title = "Effect of interleukin-2 and mitogen on in vitro immunoglobulin production by peripheral blood lymphocytes from patients with selective IgM deficiency",

abstract = "Immunoglobulin production by mitogen and recombinant interleukin-2-(rIL-2)-stimulated lymphocytes from IgM-deficient patients was studied. The findings were that subnormal serum IgM levels did not necessarily predict defective in vitro IgG or IgM production, lymphocytes from some IgM-deficient patients exhibited defective T cell function, and rIL-2 did not enhance defective in vitro immunoglobulin production.",

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AU - Moffitt, J. E.

AU - Guill, Margaret Frank

AU - Wray, Betty Beasley

AU - Brown, D. A.

AU - Peacocke, N. W.

AU - Ades, E. W.

PY - 1988/12/1

Y1 - 1988/12/1

N2 - Immunoglobulin production by mitogen and recombinant interleukin-2-(rIL-2)-stimulated lymphocytes from IgM-deficient patients was studied. The findings were that subnormal serum IgM levels did not necessarily predict defective in vitro IgG or IgM production, lymphocytes from some IgM-deficient patients exhibited defective T cell function, and rIL-2 did not enhance defective in vitro immunoglobulin production.

AB - Immunoglobulin production by mitogen and recombinant interleukin-2-(rIL-2)-stimulated lymphocytes from IgM-deficient patients was studied. The findings were that subnormal serum IgM levels did not necessarily predict defective in vitro IgG or IgM production, lymphocytes from some IgM-deficient patients exhibited defective T cell function, and rIL-2 did not enhance defective in vitro immunoglobulin production.

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M3 - Article

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SN - 0003-4738

VL - 61

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EP - 427

JO - Annals of Allergy

JF - Annals of Allergy

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ER -

Effect of interleukin-2 and mitogen on in vitro immunoglobulin production by peripheral blood lymphocytes from patients with selective IgM deficiency

Abstract

ASJC Scopus subject areas

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