Effect of low level exposure of lead and cadmium on hepatic estradiol metabolism in female rats

Anil Pillai, Laxmipriya, Ami Rawal, Sarita Gupta

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Toxic effect of metal cations on female reproduction and gonadal functions was studied. Adult synchronized female rats were treated intraperitoneally with lead acetate and cadmium acetate separately and in combination (0.025, 0.05 and 0.1 mg/kg body wt) for 15 days. The metabolizing enzymes (17β-hydroxy steroid oxidoreductase and UDP glucoronyl transferase) activities decreased with increasing dose showing significant change compared to control. Also, significant decrease in cytochrome P450 (CYP450) content was found after the treatment. Displacement of zinc bound to metallothionein was more in cadmium treated rats compared to other groups. In all these parameters, treatment in combination of lead and cadmium showed intermediate results indicating some kind of competition between the two metals. But the histological studies showed that combined treatment caused more cytotoxic effect than cadmium and lead alone. These results indicated that metal cations tested did have a direct inhibitory effect on metabolizing enzyme activities.

Original languageEnglish (US)
Pages (from-to)807-811
Number of pages5
JournalIndian Journal of Experimental Biology
Issue number7
StatePublished - Jul 25 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology


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