Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes

Kimberly Ann S. Inouye, Frederick C. Bisch, Mohammed E. Elsalanty, Ibrahim Zakhary, Rania M. Khashaba, James L. Borke

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


PURPOSE:: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS:: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS:: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS:: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.

Original languageEnglish (US)
Pages (from-to)319-327
Number of pages9
JournalImplant Dentistry
Issue number3
StatePublished - Jun 2014
Externally publishedYes


  • Dental implants
  • Metformin
  • Rat model
  • Type 2 diabetes

ASJC Scopus subject areas

  • Oral Surgery


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