Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes

Kimberly Ann S. Inouye; Frederick C. Bisch; Mohammed E. Elsalanty; Ibrahim Zakhary; Rania M. Khashaba; James L. Borke

doi:10.1097/ID.0000000000000069

Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes

Kimberly Ann S. Inouye, Frederick C. Bisch, Mohammed E. Elsalanty, Ibrahim Zakhary, Rania M. Khashaba, James L. Borke

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

PURPOSE:: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS:: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS:: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS:: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.

Original language	English (US)
Pages (from-to)	319-327
Number of pages	9
Journal	Implant Dentistry
Volume	23
Issue number	3
DOIs	https://doi.org/10.1097/ID.0000000000000069
State	Published - Jun 2014
Externally published	Yes

Keywords

Dental implants
Metformin
Rat model
Type 2 diabetes

ASJC Scopus subject areas

Oral Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/ID.0000000000000069

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title = "Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes",

abstract = "PURPOSE:: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS:: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS:: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS:: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.",

keywords = "Dental implants, Metformin, Rat model, Type 2 diabetes",

author = "Inouye, {Kimberly Ann S.} and Bisch, {Frederick C.} and Elsalanty, {Mohammed E.} and Ibrahim Zakhary and Khashaba, {Rania M.} and Borke, {James L.}",

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AU - Inouye, Kimberly Ann S.

AU - Bisch, Frederick C.

AU - Elsalanty, Mohammed E.

AU - Zakhary, Ibrahim

AU - Khashaba, Rania M.

AU - Borke, James L.

PY - 2014/6

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N2 - PURPOSE:: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS:: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS:: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS:: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.

AB - PURPOSE:: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS:: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS:: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS:: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.

KW - Dental implants

KW - Metformin

KW - Rat model

KW - Type 2 diabetes

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Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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